Recent Advances in Synthesis of Benzothiazole Compounds Related to Green Chemistry

Benzothiazoles have played an important role in the field of biochemistry and medicinal chemistry due to their highly pharmaceutical and biological activity. The development of synthetic processes is undoubtedly one of the most significant problems facing researchers. In this review paper, we provid...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-04, Vol.25 (7), p.1675
Main Authors: Gao, Xiang, Liu, Jiao, Zuo, Xin, Feng, Xinyue, Gao, Ying
Format: Article
Language:English
Subjects:
2-aminobenzenethiol
Acids
Aldehydes
Animals
Benzothiazole
benzothiazoles
Benzothiazoles - chemistry
Biological activity
Carbon dioxide
Carbon Dioxide - chemistry
condensation
cyclization
Green chemistry
Green Chemistry Technology - methods
Humans
Iodine
Ketones
Molecular Structure
Phenols - chemistry
Raw materials
Researchers
Review
Sulfhydryl Compounds - chemistry
thioamide
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Summary:Benzothiazoles have played an important role in the field of biochemistry and medicinal chemistry due to their highly pharmaceutical and biological activity. The development of synthetic processes is undoubtedly one of the most significant problems facing researchers. In this review paper, we provided recent advances in the synthesis of benzothiazole compounds related to green chemistry from condensation of 2-aminobenzenethiol with aldehydes/ketones/acids/acyl chlorides and the cyclization of thioamide or carbon dioxide (CO ) as raw materials, and the future development trend and prospect of the synthesis of benzothiazoles were anticipated.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25071675