Novel Serum Proteomes Expressed from Benzene Exposure Among Gasoline Station Attendants

Background: Research on the proteomes impact of benzene exposure in fuel station employees remains sparse, underscoring the need for detailed health impact assessments focusing on biomarker evaluation. Objectives: This investigation aimed to analyze the differences in blood parameters and serum prot...

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Bibliographic Details
Published in:Biomarker insights 2024-01, Vol.19, p.11772719241259604
Main Authors: Polyong, Chan Pattama, Roytrakul, Sittiruk, Sirivarasai, Jintana, Yingratanasuk, Tanongsak, Thetkathuek, Anamai
Format: Article
Language:English
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Summary:Background: Research on the proteomes impact of benzene exposure in fuel station employees remains sparse, underscoring the need for detailed health impact assessments focusing on biomarker evaluation. Objectives: This investigation aimed to analyze the differences in blood parameters and serum proteomes resulting from benzene exposure between gasoline station attendants (B-GSA) and a control group. Design and methods: A cross-sectional analytical study was conducted with 96 participants, comprising 54 in the B-GSA group and 42 in the control group. The methodology employed included an interview questionnaire alongside urine and blood sample collections. The urine samples were analyzed for trans,trans-muconic acid (t,t-MA) levels, while the blood samples underwent complete blood count analysis and proteome profiling. Results: Post-shift analysis indicated that the B-GSA group exhibited significantly higher levels of t,t-MA and monocytes compared to the control group (P 
ISSN:1177-2719
1177-2719
DOI:10.1177/11772719241259604