The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses

Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of...

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Bibliographic Details
Published in:Mediators of Inflammation 2012, Vol.2012 (2012), p.12-29-101
Main Authors: Hong, Sungyoul, Yoo, Byong Chul, Oh, Jueun, Yi, Young-Su, Byeon, Se Eun, Cho, Jae Youl
Format: Article
Language:English
Subjects:
Animals
Heme Oxygenase-1 - physiology
Humans
Inflammation - etiology
Kupffer Cells - physiology
Macrophages - physiology
NADPH Oxidases - physiology
Reactive Oxygen Species - metabolism
Review
Signal Transduction
src-Family Kinases - antagonists & inhibitors
src-Family Kinases - chemistry
src-Family Kinases - physiology
Toll-Like Receptors - physiology
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Summary:Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages. Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis. Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described. In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses. Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases. We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.
ISSN:0962-9351
1466-1861
DOI:10.1155/2012/512926