Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus

Purpose. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (G...

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Bibliographic Details
Published in:Journal of ophthalmology 2024-05, Vol.2024, p.8422747-7
Main Authors: Wu, Zhiqing, Zhang, Yaohua, Li, Yong, Yang, Fang, Su, Xirui, Gao, Yan, Wei, Shengsheng, Li, Jing
Format: Article
Language:English
Subjects:
Biomechanics
Cameras
Corneal transplantation
Diagnosis
Eye surgery
Keratoconus
Normal distribution
Patients
Software
Topography
Variance analysis
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Summary:Purpose. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3 mm, 5 mm, and 7 mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. Results. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2 mm), DA ratio max (1 mm), ARTh, integrated radius, SPA1, and CBI p
ISSN:2090-004X
2090-0058
DOI:10.1155/2024/8422747