Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus

Purpose. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (G...

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Published in:Journal of ophthalmology 2024-05, Vol.2024, p.8422747-7
Main Authors: Wu, Zhiqing, Zhang, Yaohua, Li, Yong, Yang, Fang, Su, Xirui, Gao, Yan, Wei, Shengsheng, Li, Jing
Format: Article
Language:English
Subjects:
Biomechanics
Cameras
Corneal transplantation
Diagnosis
Eye surgery
Keratoconus
Normal distribution
Patients
Software
Topography
Variance analysis
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Zhang, Yaohua
Li, Yong
Yang, Fang
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Gao, Yan
Wei, Shengsheng
Li, Jing
description Purpose. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3 mm, 5 mm, and 7 mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. Results. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2 mm), DA ratio max (1 mm), ARTh, integrated radius, SPA1, and CBI p
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To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3 mm, 5 mm, and 7 mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. Results. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2 mm), DA ratio max (1 mm), ARTh, integrated radius, SPA1, and CBI p&lt;0.01. The CVs of the Group B subgroups were significantly lower than those of Group A for each diameter range p&lt;0.05. There were significant differences between the severe, mild, and moderate subgroups for the 3 mm zone (p&lt;0.05, all). The 3 mm zone CV exhibited better diagnostic ability in each group for distinguishing KC from the normal cornea (Groups A vs. B: area under the ROC curve (AUC) = 0.926, Groups A vs. B1: AUC = 0.894, Groups A vs. B2: AUC = 0.925, Groups A vs. B3: AUC = 0.953). Conclusion. The CV significantly decreased in keratoconic eyes. Progressive thinning in the 3 mm zone may be a valuable measurement for detecting and staging KC. Combining the CV examination with corneal biomechanical information may effectively enhance the ability to detect KC.</description><identifier>ISSN: 2090-004X</identifier><identifier>EISSN: 2090-0058</identifier><identifier>DOI: 10.1155/2024/8422747</identifier><identifier>PMID: 38841207</identifier><language>eng</language><publisher>United States: Wiley</publisher><subject>Biomechanics ; Cameras ; Corneal transplantation ; Diagnosis ; Eye surgery ; Keratoconus ; Normal distribution ; Patients ; Software ; Topography ; Variance analysis</subject><ispartof>Journal of ophthalmology, 2024-05, Vol.2024, p.8422747-7</ispartof><rights>Copyright © 2024 Zhiqing Wu et al.</rights><rights>COPYRIGHT 2024 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2024 Zhiqing Wu et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024 Zhiqing Wu et al. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c500t-819f1e83206e517501d66f6fcc7c7cf5cdef6e18e0906b99fafbe70b9a08edb3</cites><orcidid>0000-0003-2066-7593 ; 0009-0006-0995-7126 ; 0000-0002-1914-5723 ; 0009-0006-5908-9769 ; 0009-0001-7498-0473 ; 0009-0005-5085-2943 ; 0009-0005-0590-8442 ; 0009-0009-2719-9367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3065746717/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3065746717?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38841207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bohac, Maja</contributor><contributor>Maja Bohac</contributor><creatorcontrib>Wu, Zhiqing</creatorcontrib><creatorcontrib>Zhang, Yaohua</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Yang, Fang</creatorcontrib><creatorcontrib>Su, Xirui</creatorcontrib><creatorcontrib>Gao, Yan</creatorcontrib><creatorcontrib>Wei, Shengsheng</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><title>Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus</title><title>Journal of ophthalmology</title><addtitle>J Ophthalmol</addtitle><description>Purpose. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3 mm, 5 mm, and 7 mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. Results. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2 mm), DA ratio max (1 mm), ARTh, integrated radius, SPA1, and CBI p&lt;0.01. The CVs of the Group B subgroups were significantly lower than those of Group A for each diameter range p&lt;0.05. There were significant differences between the severe, mild, and moderate subgroups for the 3 mm zone (p&lt;0.05, all). The 3 mm zone CV exhibited better diagnostic ability in each group for distinguishing KC from the normal cornea (Groups A vs. B: area under the ROC curve (AUC) = 0.926, Groups A vs. B1: AUC = 0.894, Groups A vs. B2: AUC = 0.925, Groups A vs. B3: AUC = 0.953). Conclusion. The CV significantly decreased in keratoconic eyes. Progressive thinning in the 3 mm zone may be a valuable measurement for detecting and staging KC. Combining the CV examination with corneal biomechanical information may effectively enhance the ability to detect KC.</description><subject>Biomechanics</subject><subject>Cameras</subject><subject>Corneal transplantation</subject><subject>Diagnosis</subject><subject>Eye surgery</subject><subject>Keratoconus</subject><subject>Normal distribution</subject><subject>Patients</subject><subject>Software</subject><subject>Topography</subject><subject>Variance analysis</subject><issn>2090-004X</issn><issn>2090-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1v1DAQhiMEolXpjTOKhISQyrZ2EsfJCZXlq6ISh1aImzVxxlmvEru1E6oe-efMfrB0EcI-2B4_81qeeZPkOWennAtxlrGsOKuKLJOFfJQcZqxmM8ZE9Xi3L74fJMcxLhmNnBdCsKfJQV5VBc-YPEx-zn0I2MNovUsbHO8QXUoxh9Cn33w_DZiCa3ehd9YPqBfgrI57F1v2ynbOGqvBaUytS69G6Kzr1uh7C53zcXX8ggFGr72b4rPkiYE-4vF2PUquP364nn-eXX79dDE_v5xpwdg4q3htOFZ5xkoUXArG27I0pdFa0jRCt2hK5BXSt8umrg2YBiVramAVtk1-lFxsZFsPS3UT7ADhXnmwah3woVMQRqt7VC2iRsNErsEUyGUNum20zqUUjSilIa23G62bqRmw1ejGAP2e6P6NswvV-R-KU9MyWTJSeL1VCP52wjiqwUaNfQ8O_RRVzkoCi5JXhL78C136KTgq1ZoiSHL5h-qAfmCd8fSwXomqc1lLlolccKJO_0HRbHGw1A00luJ7Ca8eJCyo0eMiUqdXdon74JsNqIOPMaDZVYMztbKqWllVba1K-IuHFdzBv41JwMkGWFjXwp39v9wveKnxBw</recordid><startdate>20240529</startdate><enddate>20240529</enddate><creator>Wu, Zhiqing</creator><creator>Zhang, Yaohua</creator><creator>Li, Yong</creator><creator>Yang, Fang</creator><creator>Su, Xirui</creator><creator>Gao, Yan</creator><creator>Wei, Shengsheng</creator><creator>Li, Jing</creator><general>Wiley</general><general>John Wiley &amp; 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To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3 mm, 5 mm, and 7 mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. Results. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2 mm), DA ratio max (1 mm), ARTh, integrated radius, SPA1, and CBI p&lt;0.01. The CVs of the Group B subgroups were significantly lower than those of Group A for each diameter range p&lt;0.05. There were significant differences between the severe, mild, and moderate subgroups for the 3 mm zone (p&lt;0.05, all). The 3 mm zone CV exhibited better diagnostic ability in each group for distinguishing KC from the normal cornea (Groups A vs. B: area under the ROC curve (AUC) = 0.926, Groups A vs. B1: AUC = 0.894, Groups A vs. B2: AUC = 0.925, Groups A vs. B3: AUC = 0.953). Conclusion. The CV significantly decreased in keratoconic eyes. Progressive thinning in the 3 mm zone may be a valuable measurement for detecting and staging KC. 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subjects Biomechanics
Cameras
Corneal transplantation
Diagnosis
Eye surgery
Keratoconus
Normal distribution
Patients
Software
Topography
Variance analysis
title Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus
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