Evaluation of sucralfate enema in experimental diversion colitis

Abstract Diversion colitis (DC) is an inflammatory disease that develops in segments with fecal di- version. Sucralfate (SCF) complex, which consists of sucrose octasulfate and polyaluminum hydroxide, has been demonstrated to be effective in the treatment of different forms of colitis. However, unti...

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Bibliographic Details
Published in:Journal of Coloproctology 2013-12, Vol.33 (4), p.182-190
Main Authors: Pereira, José Aires, Rodrigues, Murilo Rocha, Sato, Daniela Tiemi, Júnior, Paulo Pedroso Silveira, Dias, Alice Moreira, Silva, Camila Gonçalves da, Martinez, Carlos Augusto Real
Format: Article
Language:English
Subjects:
Colite experimental
Colon
Cólon
Experimental colitis
GASTROENTEROLOGY & HEPATOLOGY
Gastroenterology and Hepatology
Original article
Ratos
Rats
Short chain fatty acids
Sucralfate
Sucralfato
SURGERY
Ácidos graxos de cadeia curta
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Summary:Abstract Diversion colitis (DC) is an inflammatory disease that develops in segments with fecal di- version. Sucralfate (SCF) complex, which consists of sucrose octasulfate and polyaluminum hydroxide, has been demonstrated to be effective in the treatment of different forms of colitis. However, until now, the effects of SCF have not been evaluated in DC. Objective to evaluate whether the use of enemas containing SFC improves histological find- ings in experimental DC. Methods Thirty-six rats underwent right colon bypass procedure through the creation of a proximal colostomy and a distal mucous fistula. The animals were divided into two groups according to the euthanization procedure to be performed two to four weeks after sur- gery. Each experimental group was divided into three subgroups of six animals, which were submitted to daily application of enemas containing saline solution 0.9% or SCF at con- centrations of 1.0 g/kg/day or 2.0 g/kg/day, respectively. The diagnosis of DC in segments with fecal diversion was established by histopathological study considering the following variables epithelial loss, formation of crypt abscesses, the population of goblet cells, in- flammatory infiltrate and presence of fibrosis. For statistical analysis, the nonparametric Mann-Whitney and Kruskal-Wallis tests were used, with a significance level of 5% (p
ISSN:2237-9363
2317-6423
2317-6423
DOI:10.1016/j.jcol.2013.08.005