Silk fibroin scaffolds: A promising candidate for bone regeneration

It remains a big challenge in clinical practice to repair large-sized bone defects and many factors limit the application of autografts and allografts, The application of exogenous scaffolds is an alternate strategy for bone regeneration, among which the silk fibroin (SF) scaffold is a promising can...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-11, Vol.10, p.1054379-1054379
Main Authors: Wu, Hao, Lin, Kaili, Zhao, Cancan, Wang, Xudong
Format: Article
Language:English
Subjects:
biocompatibility
biodegradability
Bioengineering and Biotechnology
bone regeneration
osteogenesis
scaffolds
silk fibroin (SF)
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Summary:It remains a big challenge in clinical practice to repair large-sized bone defects and many factors limit the application of autografts and allografts, The application of exogenous scaffolds is an alternate strategy for bone regeneration, among which the silk fibroin (SF) scaffold is a promising candidate. Due to the advantages of excellent biocompatibility, satisfying mechanical property, controllable biodegradability and structural adjustability, SF scaffolds exhibit great potential in bone regeneration with the help of well-designed structures, bioactive components and functional surface modification. This review will summarize the cell and tissue interaction with SF scaffolds, techniques to fabricate SF-based scaffolds and modifications of SF scaffolds to enhance osteogenesis, which will provide a deep and comprehensive insight into SF scaffolds and inspire the design and fabrication of novel SF scaffolds for superior osteogenic performance. However, there still needs more comprehensive efforts to promote better clinical translation of SF scaffolds, including more experiments in big animal models and clinical trials. Furthermore, deeper investigations are also in demand to reveal the degradation and clearing mechanisms of SF scaffolds and evaluate the influence of degradation products.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.1054379