The physiologic response to rescue therapy with vasopressin versus epinephrine during experimental pediatric cardiac arrest

Compare vasopressin to a second dose of epinephrine as rescue therapy after ineffective initial doses of epinephrine in diverse models of pediatric in-hospital cardiac arrest. 67 one- to three-month old female swine (10−30kg) in six experimental cohorts from one laboratory received hemodynamic-direc...

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Bibliographic Details
Published in:Resuscitation plus 2020-12, Vol.4, p.100050-100050, Article 100050
Main Authors: Slovis, Julia C., Morgan, Ryan W., Landis, William P., Roberts, Anna L., Marquez, Alexandra M., Mavroudis, Constantine D., Lin, Yuxi, Ko, Tiffany, Nadkarni, Vinay M., Berg, Robert A., Sutton, Robert M., Kilbaugh, Todd J.
Format: Article
Language:English
Subjects:
Cardiac arrest
Cardiopulmonary resuscitation
Cerebral blood flow
Coronary perfusion pressure
Epinephrine
Experimental Paper
Pediatrics
Vasopressin
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Summary:Compare vasopressin to a second dose of epinephrine as rescue therapy after ineffective initial doses of epinephrine in diverse models of pediatric in-hospital cardiac arrest. 67 one- to three-month old female swine (10−30kg) in six experimental cohorts from one laboratory received hemodynamic-directed CPR, a resuscitation method where high quality chest compressions are provided and vasopressor administration is titrated to coronary perfusion pressure (CoPP) ≥20mmHg. Vasopressors are given when CoPP is
ISSN:2666-5204
2666-5204
DOI:10.1016/j.resplu.2020.100050