Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex): Postscript and Historical Footnote

Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of the U.S. territory of Guam, Papua-Indonesia (New Guinea) and Kii Peninsula, Honshu Island, Japan (Muro disease). We report addi...

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Bibliographic Details
Published in:eNeurologicalSci 2021-03, Vol.22, p.100308-100308, Article 100308
Main Authors: Spencer, Peter S., Palmer, Valerie S., Kihira, Tameko, Yoshida, Sohei, Reis, Jacques, Yabushita, Momoko, Yase, Yoshiro
Format: Article
Language:English
Subjects:
Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex
Chamber of Iron Cycads
Filial piety
Letter to the Editor
Mitogawa, Kii Peninsula Honshu, Japan
Traditional/folk medical practice
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Summary:Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of the U.S. territory of Guam, Papua-Indonesia (New Guinea) and Kii Peninsula, Honshu Island, Japan (Muro disease). We report additional data that associate medicinal use of cycad seed to Muro disease in the southern Kozagawa focus of ALS/PDC. In the other two ALS/PDC-affected populations, cycad seed was used as a traditional topical medicine in New Guinea and Guam and, additionally, for food on Guam.
ISSN:2405-6502
2405-6502
DOI:10.1016/j.ensci.2020.100308