Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies

Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients wi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of immunology research 2017-01, Vol.2017, p.7304658-8
Main Authors: Kralickova, P., Kuhnova, J., Soucek, O., Vodarek, P., Zak, P., Simkovic, M., Motyckova, M., Smolej, L., Mala, E., Andrys, C., Krejsek, J., Thon, V.
Format: Article
Language:English
Subjects:
Age
Antigens
Bacterial infections
Capsular polysaccharides
Chronic lymphocytic leukemia
Common variable immunodeficiency
Hematology
Hospitals
Immune system
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Immunology
Infectious diseases
Leukemia
Medicine
Older people
Polysaccharides
Production capacity
Saccharides
Streptococcus infections
Vaccines
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients with common variable immunodeficiency (CVID), and (3) a healthy population and to explore their diagnostic and prognostic potential. Serum immunoglobulin levels and levels of anti-Gal IgG, IgA, and IgM and anti-PCP IgG and IgG2 were determined in 59 CLL patients, 30 CVID patients, and 67 healthy controls. Levels of IgG, IgA, IgM, anti-Gal IgA, anti-Gal IgM, and anti-PCP IgA were lower in CLL and CVID patients than in healthy controls (p value for all parameters
ISSN:2314-8861
2314-7156
DOI:10.1155/2017/7304658