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Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation
The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis is a kind of iron-dependent necrosis featured by significantly Fe -dependent lipid peroxidation. The ongoing study aimed to reinforce fertility by combining therapy...
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| Published in: | Redox report : communications in free radical research 2025-12, Vol.30 (1), p.2445398 |
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| creator | Eltokhy, Amira K El-Shaer, Rehab Ahmed Ahmed El-Deeb, Omnia Safwat Farghal, Eman E Ibrahim, Rowida Raafat Elesawy, Rasha Awad, Marwa Mahmoud Ismail, Radwa Motawea, Shaimaa M Shatat, Doaa Hafez, Yasser Mostafa El Hanafy, Hend Ahmed Atef, Marwa Mohamed |
| description | The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis is a kind of iron-dependent necrosis featured by significantly Fe
-dependent lipid peroxidation. The ongoing study aimed to reinforce fertility by combining therapy with AgNPs and (Zileuton) in PCOS rats' model.
The study included 75 adult female rats divided into 5 groups; control, PCOS, PCOS treated with AgNPs, PCOS treated with Zileuton, and PCOS group treated with AgNPs and Zileuton. The study investigated the anti-ferroptotic, anti-inflammatory, antioxidant, antiapoptotic, histopathological and immunohistochemical examinations of COX-2 and VEGF.
The combination of AgNPs and Zileuton showed significant reduction of inflammatory mediators (IL-6, TNF-α, NFk-B) compared with diseased group (
-
|
| doi_str_mv | 10.1080/13510002.2024.2445398 |
| format | article |
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-dependent lipid peroxidation. The ongoing study aimed to reinforce fertility by combining therapy with AgNPs and (Zileuton) in PCOS rats' model.
The study included 75 adult female rats divided into 5 groups; control, PCOS, PCOS treated with AgNPs, PCOS treated with Zileuton, and PCOS group treated with AgNPs and Zileuton. The study investigated the anti-ferroptotic, anti-inflammatory, antioxidant, antiapoptotic, histopathological and immunohistochemical examinations of COX-2 and VEGF.
The combination of AgNPs and Zileuton showed significant reduction of inflammatory mediators (IL-6, TNF-α, NFk-B) compared with diseased group (
-
< 0.05), regression of ferroptosis marks (Panx1 and TLR4 expression, Fe
levels) compared with diseased group (
-
< 0.05), depression of apoptotic marker caspase 3 level compared with diseased animals (
-value < 0.05), depression of MDA level, elevation of HO-1, GPx4 activity, and reduction of Cox2 and VEGF as compared with the diseased, AgNPs or zileuton-treated groups (
-value < 0.05).
The study showed that the combination of AgNPs and zileuton guards against, inflammation, apoptosis, and ferroptosis in PCO.</description><identifier>ISSN: 1351-0002</identifier><identifier>ISSN: 1743-2928</identifier><identifier>EISSN: 1743-2928</identifier><identifier>DOI: 10.1080/13510002.2024.2445398</identifier><identifier>PMID: 39723580</identifier><language>eng</language><publisher>England: Taylor & Francis Group</publisher><subject>AgNPs ; Animals ; Antioxidants - pharmacology ; COX-2 ; Female ; Ferroptosis ; Ferroptosis - drug effects ; Hydroxyurea - analogs & derivatives ; Hydroxyurea - pharmacology ; Inflammation - drug therapy ; Inflammation - metabolism ; Metal Nanoparticles - therapeutic use ; Panx1 ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - metabolism ; Rats ; Silver ; TLR4 ; VEGF</subject><ispartof>Redox report : communications in free radical research, 2025-12, Vol.30 (1), p.2445398</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1680-447d5f628a697d9b70495d45ff94f2322efe5d4c190a939eabf2407581e4fa673</cites><orcidid>0000-0003-0222-1846</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39723580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eltokhy, Amira K</creatorcontrib><creatorcontrib>El-Shaer, Rehab Ahmed Ahmed</creatorcontrib><creatorcontrib>El-Deeb, Omnia Safwat</creatorcontrib><creatorcontrib>Farghal, Eman E</creatorcontrib><creatorcontrib>Ibrahim, Rowida Raafat</creatorcontrib><creatorcontrib>Elesawy, Rasha</creatorcontrib><creatorcontrib>Awad, Marwa Mahmoud</creatorcontrib><creatorcontrib>Ismail, Radwa</creatorcontrib><creatorcontrib>Motawea, Shaimaa M</creatorcontrib><creatorcontrib>Shatat, Doaa</creatorcontrib><creatorcontrib>Hafez, Yasser Mostafa</creatorcontrib><creatorcontrib>El Hanafy, Hend Ahmed</creatorcontrib><creatorcontrib>Atef, Marwa Mohamed</creatorcontrib><title>Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation</title><title>Redox report : communications in free radical research</title><addtitle>Redox Rep</addtitle><description>The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis is a kind of iron-dependent necrosis featured by significantly Fe
-dependent lipid peroxidation. The ongoing study aimed to reinforce fertility by combining therapy with AgNPs and (Zileuton) in PCOS rats' model.
The study included 75 adult female rats divided into 5 groups; control, PCOS, PCOS treated with AgNPs, PCOS treated with Zileuton, and PCOS group treated with AgNPs and Zileuton. The study investigated the anti-ferroptotic, anti-inflammatory, antioxidant, antiapoptotic, histopathological and immunohistochemical examinations of COX-2 and VEGF.
The combination of AgNPs and Zileuton showed significant reduction of inflammatory mediators (IL-6, TNF-α, NFk-B) compared with diseased group (
-
< 0.05), regression of ferroptosis marks (Panx1 and TLR4 expression, Fe
levels) compared with diseased group (
-
< 0.05), depression of apoptotic marker caspase 3 level compared with diseased animals (
-value < 0.05), depression of MDA level, elevation of HO-1, GPx4 activity, and reduction of Cox2 and VEGF as compared with the diseased, AgNPs or zileuton-treated groups (
-value < 0.05).
The study showed that the combination of AgNPs and zileuton guards against, inflammation, apoptosis, and ferroptosis in PCO.</description><subject>AgNPs</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>COX-2</subject><subject>Female</subject><subject>Ferroptosis</subject><subject>Ferroptosis - drug effects</subject><subject>Hydroxyurea - analogs & derivatives</subject><subject>Hydroxyurea - pharmacology</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Panx1</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Rats</subject><subject>Silver</subject><subject>TLR4</subject><subject>VEGF</subject><issn>1351-0002</issn><issn>1743-2928</issn><issn>1743-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNo9kd1rFDEUxYMotlb_BGUefZn15msmeSyLH4ViC9VHCXczN0vKzGRNZgv1rzfb3RYCOQm_e07CYewjhxUHA1-41BwAxEqAUCuhlJbWvGLnvFeyFVaY11VXpj1AZ-xdKfdVyc6at-xM2l5IbeCc_bl7nClvY1mibygE8ktpUmgutz9vS4Pz0PyLI-2XNDd13a5v7pqHiE2gnNNuSSUeoTiHEacJl1ipKS5x-yTfszcBx0IfTvsF-_3t66_1j_b65vvV-vK69bwz0CrVDzp0wmBn-8FuelBWD0qHYFUQUggKVM-eW0ArLeEmCAW9NpxUwK6XF-zq6DskvHe7HCfMjy5hdE8XKW8d5vrDkdwQgAQYvemAlJcKUXtjDXilsMaZ6vX56LXL6e-eyuKmWDyNI86U9sVJXh8nbadVRfUR9TmVkim8RHNwh5bcc0vu0JI7tVTnPp0i9puJhpep51rkfzCZjCQ</recordid><startdate>202512</startdate><enddate>202512</enddate><creator>Eltokhy, Amira K</creator><creator>El-Shaer, Rehab Ahmed Ahmed</creator><creator>El-Deeb, Omnia Safwat</creator><creator>Farghal, Eman E</creator><creator>Ibrahim, Rowida Raafat</creator><creator>Elesawy, Rasha</creator><creator>Awad, Marwa Mahmoud</creator><creator>Ismail, Radwa</creator><creator>Motawea, Shaimaa M</creator><creator>Shatat, Doaa</creator><creator>Hafez, Yasser Mostafa</creator><creator>El Hanafy, Hend Ahmed</creator><creator>Atef, Marwa Mohamed</creator><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0222-1846</orcidid></search><sort><creationdate>202512</creationdate><title>Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation</title><author>Eltokhy, Amira K ; El-Shaer, Rehab Ahmed Ahmed ; El-Deeb, Omnia Safwat ; Farghal, Eman E ; Ibrahim, Rowida Raafat ; Elesawy, Rasha ; Awad, Marwa Mahmoud ; Ismail, Radwa ; Motawea, Shaimaa M ; Shatat, Doaa ; Hafez, Yasser Mostafa ; El Hanafy, Hend Ahmed ; Atef, Marwa Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1680-447d5f628a697d9b70495d45ff94f2322efe5d4c190a939eabf2407581e4fa673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>AgNPs</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>COX-2</topic><topic>Female</topic><topic>Ferroptosis</topic><topic>Ferroptosis - drug effects</topic><topic>Hydroxyurea - analogs & derivatives</topic><topic>Hydroxyurea - pharmacology</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>Panx1</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Rats</topic><topic>Silver</topic><topic>TLR4</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eltokhy, Amira K</creatorcontrib><creatorcontrib>El-Shaer, Rehab Ahmed Ahmed</creatorcontrib><creatorcontrib>El-Deeb, Omnia Safwat</creatorcontrib><creatorcontrib>Farghal, Eman E</creatorcontrib><creatorcontrib>Ibrahim, Rowida Raafat</creatorcontrib><creatorcontrib>Elesawy, Rasha</creatorcontrib><creatorcontrib>Awad, Marwa Mahmoud</creatorcontrib><creatorcontrib>Ismail, Radwa</creatorcontrib><creatorcontrib>Motawea, Shaimaa M</creatorcontrib><creatorcontrib>Shatat, Doaa</creatorcontrib><creatorcontrib>Hafez, Yasser Mostafa</creatorcontrib><creatorcontrib>El Hanafy, Hend Ahmed</creatorcontrib><creatorcontrib>Atef, Marwa Mohamed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Redox report : communications in free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eltokhy, Amira K</au><au>El-Shaer, Rehab Ahmed Ahmed</au><au>El-Deeb, Omnia Safwat</au><au>Farghal, Eman E</au><au>Ibrahim, Rowida Raafat</au><au>Elesawy, Rasha</au><au>Awad, Marwa Mahmoud</au><au>Ismail, Radwa</au><au>Motawea, Shaimaa M</au><au>Shatat, Doaa</au><au>Hafez, Yasser Mostafa</au><au>El Hanafy, Hend Ahmed</au><au>Atef, Marwa Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation</atitle><jtitle>Redox report : communications in free radical research</jtitle><addtitle>Redox Rep</addtitle><date>2025-12</date><risdate>2025</risdate><volume>30</volume><issue>1</issue><spage>2445398</spage><pages>2445398-</pages><issn>1351-0002</issn><issn>1743-2928</issn><eissn>1743-2928</eissn><abstract>The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis is a kind of iron-dependent necrosis featured by significantly Fe
-dependent lipid peroxidation. The ongoing study aimed to reinforce fertility by combining therapy with AgNPs and (Zileuton) in PCOS rats' model.
The study included 75 adult female rats divided into 5 groups; control, PCOS, PCOS treated with AgNPs, PCOS treated with Zileuton, and PCOS group treated with AgNPs and Zileuton. The study investigated the anti-ferroptotic, anti-inflammatory, antioxidant, antiapoptotic, histopathological and immunohistochemical examinations of COX-2 and VEGF.
The combination of AgNPs and Zileuton showed significant reduction of inflammatory mediators (IL-6, TNF-α, NFk-B) compared with diseased group (
-
< 0.05), regression of ferroptosis marks (Panx1 and TLR4 expression, Fe
levels) compared with diseased group (
-
< 0.05), depression of apoptotic marker caspase 3 level compared with diseased animals (
-value < 0.05), depression of MDA level, elevation of HO-1, GPx4 activity, and reduction of Cox2 and VEGF as compared with the diseased, AgNPs or zileuton-treated groups (
-value < 0.05).
The study showed that the combination of AgNPs and zileuton guards against, inflammation, apoptosis, and ferroptosis in PCO.</abstract><cop>England</cop><pub>Taylor & Francis Group</pub><pmid>39723580</pmid><doi>10.1080/13510002.2024.2445398</doi><orcidid>https://orcid.org/0000-0003-0222-1846</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Redox report : communications in free radical research, 2025-12, Vol.30 (1), p.2445398 |
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| source | Taylor & Francis Open Access; PubMed Central |
| subjects | AgNPs Animals Antioxidants - pharmacology COX-2 Female Ferroptosis Ferroptosis - drug effects Hydroxyurea - analogs & derivatives Hydroxyurea - pharmacology Inflammation - drug therapy Inflammation - metabolism Metal Nanoparticles - therapeutic use Panx1 Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - metabolism Rats Silver TLR4 VEGF |
| title | Synergistic effects of AgNPs and zileuton on PCOS via ferroptosis and inflammation mitigation |
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