Harnessing Neurogenesis and Neuroplasticity with Stem Cell Treatment for Addictive Disorders

Drug and alcohol addiction has become an emerging public health issue and is a great burden to patients, their families, and society. It is characterized by high relapse rates and significant morbidity and mortality, and most available treatments result in only modest improvement. These findings hig...

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Bibliographic Details
Published in:Cell Transplantation 2019-09, Vol.28 (9-10), p.1127-1131
Main Authors: Tsai, Sheng-Tzung, Liew, Hock-Kean, Li, Hao-Ming, Lin, Shinn-Zong, Chen, Shin-Yuan
Format: Article
Language:English
Subjects:
Addictions
Drug addiction
Hippocampal plasticity
Hippocampus
Morbidity
Neurogenesis
Neuroplasticity
Neurotrophic factors
Public health
Reviews
Stem cells
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Summary:Drug and alcohol addiction has become an emerging public health issue and is a great burden to patients, their families, and society. It is characterized by high relapse rates and significant morbidity and mortality, and most available treatments result in only modest improvement. These findings highlight the necessity for new approaches to treat addiction. Scientific reports in the past two decades suggest that addiction involves impaired neural plasticity and decreased hippocampal neurogenesis. Stem cell therapy and its derived neurotrophic factors can potentially target the underlying pathophysiology of addiction. Stem cell applications are showing promise in several preclinical studies and may provide new and noninvasive treatment strategies. Future clinical research is warranted to investigate whether stem cell-based therapy could support the treatment of addiction.
ISSN:0963-6897
1555-3892
DOI:10.1177/0963689719859299