Exercise as a diagnostic and therapeutic tool for preventing cardiovascular morbidity in breast cancer patients- the BReast cancer EXercise InTervention (BREXIT) trial protocol

Anthracycline chemotherapy (AC) is an efficacious (neo) adjuvant treatment for early-stage breast cancer (BCa), but is associated with an increased risk of cardiac dysfunction and functional disability. Observations suggest that regular exercise may be a useful therapy for the prevention of cardiova...

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Bibliographic Details
Published in:BMC cancer 2020-07, Vol.20 (1), p.655-16, Article 655
Main Authors: Foulkes, Stephen J, Howden, Erin J, Antill, Yoland, Loi, Sherene, Salim, Agus, Haykowsky, Mark J, Daly, Robin M, Fraser, Steve F, La Gerche, Andre
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Adult
Aged
Anthracycline
Anthracyclines - adverse effects
Body composition
Bone composition
Bone density
Bone mineral density
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Brexit
Cancer patients
Cancer Survivors - statistics & numerical data
Cancer therapies
Cardiac function
Cardiac reserve
Cardiotoxicity
Cardiotoxicity - diagnosis
Cardiotoxicity - etiology
Cardiotoxicity - therapy
Cardiovascular disease
Cardiovascular Diseases - chemically induced
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - prevention & control
Chemotherapy
Clinical trials
Cognitive ability
Contraindications
Diagnostic imaging
Disability
Drug therapy
Echocardiography
Exercise
Exercise therapy
Exercise Therapy - methods
Exercise training
Female
Fitness training programs
Follow-Up Studies
Health aspects
Heart failure
Humans
Magnetic resonance imaging
Medical prognosis
Medical research
Middle Aged
Morbidity
Mortality
Muscle strength
Patients
Physical activity
Physical fitness
Physical training
Physiological aspects
Prevention
Prognosis
Quality of life
Randomized Controlled Trials as Topic
Study Protocol
Ventricle
Womens health
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Description
Summary:Anthracycline chemotherapy (AC) is an efficacious (neo) adjuvant treatment for early-stage breast cancer (BCa), but is associated with an increased risk of cardiac dysfunction and functional disability. Observations suggest that regular exercise may be a useful therapy for the prevention of cardiovascular morbidity but it is yet to be interrogated in a large randomised trial. The primary aims of this study are to: 1) determine if 12-months of ET commenced at the onset of AC can reduce the proportion of BCa patients with functional disability (peak VO ,
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-07123-6