Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2018-05, Vol.8 (1), p.7134-12, Article 7134
Main Authors: Christian, Paul, Tumphart, Stephan, Ehmann, Heike M. A., Riegler, Hans, Coclite, Anna Maria, Werzer, Oliver
Format: Article
Language:English
Subjects:
132/122
639/301
692/4017
Coatings
Ethylene glycol
Humanities and Social Sciences
Hydrogels
Indomethacin
multidisciplinary
Polymers
Science
Science (multidisciplinary)
Thin films
Vapors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-24238-w