Therapeutic implications of cancer stem cells in prostate cancer

Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations...

Full description

Saved in:
Bibliographic Details
Published in:Cancer biology & medicine 2023-06, Vol.20 (6), p.1-20
Main Authors: Banerjee, Pinaki, Kapse, Prachi, Siddique, Shehnaz, Kundu, Moumita, Choudhari, Jasoda, Mohanty, Varshasnata, Malhotra, Diksha, Gosavi, Suresh W, Gacche, Rajesh N, Kundu, Gopal C
Format: Article
Language:English
Subjects:
cancer stem cells
Cell Differentiation
Disease Progression
epithelial-mesenchymal transition
Humans
Male
metastasis
Neoplastic Stem Cells - pathology
prostate cancer
Prostatic Neoplasms - genetics
Review
Signal Transduction
signaling
tumor growth
tumor microenvironment
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.
ISSN:2095-3941
DOI:10.20892/j.issn.2095-3941.2022.0714