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The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages
The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, lept...
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Published in: | International Journal of Endocrinology 2016, Vol.2016 (2016), p.22-32-103 |
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container_end_page | 32-103 |
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container_title | International Journal of Endocrinology |
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creator | Gong, Fengying Wu, Qinyong Wang, Lin jie Zhang, Dian xi Li, Naishi Pan, Hui Li, Su juan Zhu, Hui juan Yang, Hong bo |
description | The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P |
doi_str_mv | 10.1155/2016/6790794 |
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A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P<0.05). Conversely, serum kisspeptin levels of boys were higher in T4 and T5 stages than those in T1 stage, while its levels of girls were the highest in T2 stage, 21.4% higher than those in T1 stage (P<0.05). Both leptin and kisspeptin levels were positively correlated with BMI, WC, and weight in all boys and girls (all P<0.05). In conclusion, kisspeptin levels were firstly found to be notably changed in pubertal stages and nutritional status in Chinese children and adolescents with a significant sexual dimorphism. Obese/overweight girls had higher kisspeptin levels, and there was a positive correlation between kisspeptin and FSH and LH and obesity-related parameters in all boys and girls.</description><identifier>ISSN: 1687-8337</identifier><identifier>EISSN: 1687-8345</identifier><identifier>DOI: 10.1155/2016/6790794</identifier><identifier>PMID: 27990162</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Age ; Body fat ; Body mass index ; Children & youth ; Cholesterol ; Endocrinology ; Females ; Genetic aspects ; Girls ; Hypothalamus ; Laboratories ; Leptin ; Mutation ; Obesity ; Physiological aspects ; Puberty ; Teenagers ; Weight control</subject><ispartof>International Journal of Endocrinology, 2016, Vol.2016 (2016), p.22-32-103</ispartof><rights>Copyright © 2016 Hui juan Zhu et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Hui juan Zhu et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2016 Hui juan Zhu et al. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a6214-abbe4b6f3979e280705158b0d063f283728ddc0bb3ae26503e04d1e6656af6c43</citedby><cites>FETCH-LOGICAL-a6214-abbe4b6f3979e280705158b0d063f283728ddc0bb3ae26503e04d1e6656af6c43</cites><orcidid>0000-0002-6361-3811</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2407662391/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2407662391?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4022,25752,27922,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27990162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dufau, Maria L.</contributor><contributor>Maria L Dufau</contributor><creatorcontrib>Gong, Fengying</creatorcontrib><creatorcontrib>Wu, Qinyong</creatorcontrib><creatorcontrib>Wang, Lin jie</creatorcontrib><creatorcontrib>Zhang, Dian xi</creatorcontrib><creatorcontrib>Li, Naishi</creatorcontrib><creatorcontrib>Pan, Hui</creatorcontrib><creatorcontrib>Li, Su juan</creatorcontrib><creatorcontrib>Zhu, Hui juan</creatorcontrib><creatorcontrib>Yang, Hong bo</creatorcontrib><title>The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages</title><title>International Journal of Endocrinology</title><addtitle>Int J Endocrinol</addtitle><description>The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P<0.05). Conversely, serum kisspeptin levels of boys were higher in T4 and T5 stages than those in T1 stage, while its levels of girls were the highest in T2 stage, 21.4% higher than those in T1 stage (P<0.05). Both leptin and kisspeptin levels were positively correlated with BMI, WC, and weight in all boys and girls (all P<0.05). In conclusion, kisspeptin levels were firstly found to be notably changed in pubertal stages and nutritional status in Chinese children and adolescents with a significant sexual dimorphism. Obese/overweight girls had higher kisspeptin levels, and there was a positive correlation between kisspeptin and FSH and LH and obesity-related parameters in all boys and girls.</description><subject>Age</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Children & youth</subject><subject>Cholesterol</subject><subject>Endocrinology</subject><subject>Females</subject><subject>Genetic aspects</subject><subject>Girls</subject><subject>Hypothalamus</subject><subject>Laboratories</subject><subject>Leptin</subject><subject>Mutation</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Puberty</subject><subject>Teenagers</subject><subject>Weight control</subject><issn>1687-8337</issn><issn>1687-8345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQQCMEoqVw44wiISEk2HZsx058QaqWr4oVVGo5W0483nWVjbd2UsS_x9ksbbfigHKwPX7znBlNlr0kcEwI5ycUiDgRpYRSFo-yQyKqclaxgj--3bPyIHsW4xWAEALI0-yAllKmNHqYhcsV5vOV7pYYc2_zCwzDOl_gpnddrjuTf3MxbqbjAm-wjXnazVeuwzgmutYEnMhT41uMDXb9lvnorMV01-fnQ42h121-0ev0zPPsidVtxBe79Sj7-fnT5fzrbPHjy9n8dDHTgpJipusai1pYJkuJtIISOOFVDQYEs7RiJa2MaaCumUYqODCEwhAUggttRVOwo-xs8hqvr9QmuLUOv5XXTm0DPiyVDr1rWlTGCpbMQhfaFlQWukHkjFeEGSFLGF0fJtdmqNdoxiKDbvek-zedW6mlv1GcMMEkTYK3O0Hw1wPGXq1d6lXb6g79EBWpOKGV5IQk9PUD9MoPoUutUrSAUgjK5D1qqVMBrrM-vduMUnXKQRIBHMpEHf-DSp_BtWt8h9al-F7Cm3sJK9Rtv4q-HXrnu7gPvp_AJvgYA9rbZhBQ42CqcTDVbjAT_up-A2_hv5OYgHcTkEbL6F_uP3WYGLT6jibApRiB7xOgXXC9u2vh-ehJVUgAunWS7VICS2EA-eBAFaPpFxj7A4GdBmA</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Gong, Fengying</creator><creator>Wu, Qinyong</creator><creator>Wang, Lin jie</creator><creator>Zhang, Dian xi</creator><creator>Li, Naishi</creator><creator>Pan, Hui</creator><creator>Li, Su juan</creator><creator>Zhu, Hui juan</creator><creator>Yang, Hong bo</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6361-3811</orcidid></search><sort><creationdate>2016</creationdate><title>The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages</title><author>Gong, Fengying ; 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A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P<0.05). Conversely, serum kisspeptin levels of boys were higher in T4 and T5 stages than those in T1 stage, while its levels of girls were the highest in T2 stage, 21.4% higher than those in T1 stage (P<0.05). Both leptin and kisspeptin levels were positively correlated with BMI, WC, and weight in all boys and girls (all P<0.05). In conclusion, kisspeptin levels were firstly found to be notably changed in pubertal stages and nutritional status in Chinese children and adolescents with a significant sexual dimorphism. Obese/overweight girls had higher kisspeptin levels, and there was a positive correlation between kisspeptin and FSH and LH and obesity-related parameters in all boys and girls.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>27990162</pmid><doi>10.1155/2016/6790794</doi><orcidid>https://orcid.org/0000-0002-6361-3811</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Body fat Body mass index Children & youth Cholesterol Endocrinology Females Genetic aspects Girls Hypothalamus Laboratories Leptin Mutation Obesity Physiological aspects Puberty Teenagers Weight control |
title | The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages |
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