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Leveraging Senescent Cancer Cell Membrane to Potentiate Cancer Immunotherapy Through Biomimetic Nanovaccine

Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cancer cell‐based vaccination is limited by interference from immunosuppressive senescence‐...

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Bibliographic Details
Published in:Advanced science 2024-08, Vol.11 (30), p.e2400630-n/a
Main Authors: Yang, Chao, Chen, Yinglu, Liu, Jie, Zhang, Wensheng, He, Yan, Chen, Fangman, Xie, Xiaochun, Tang, Jie, Guan, Shan, Shao, Dan, Wang, Zheng, Wang, Liang
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Language:English
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Summary:Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cancer cell‐based vaccination is limited by interference from immunosuppressive senescence‐associated secretory phenotype and pro‐tumorigenic capacity of senescent cells. Here, a senescent cancer cell‐based nanovaccine with strong immunogenicity and favorable potential for immunotherapy is reported. The biomimetic nanovaccine integrating a senescent cancer cell membrane‐coated nanoadjuvant outperforms living senescent cancer cells in enhancing dendritic cells (DCs) internalization, improving lymph node targeting, and enhancing immune responses. In contrast to nanovaccines generated from immunogenic cell death‐induced tumor cells, senescent nanovaccines facilitate DC maturation, eliciting superior antitumor protection and improving therapeutic outcomes in melanoma‐challenged mice with fewer side effects when combined with αPD‐1. The study suggests a versatile biomanufacturing approach to maximize immunogenic potential and minimize adverse effects of senescent cancer cell‐based vaccination and advances the design of biomimetic nanovaccines for cancer immunotherapy. To overcome the limitations of senescent cancer cell‐based vaccines, a biomimetic strategy in which senescent cancer cell membranes are integrated with nanoadjuvants is created to increase the efficacy and safety of nanovaccines. In contrast to nanovaccines generated from immunogenic cell death‐induced cancer cells, senescent nanovaccines facilitate dendritic cell maturation, eliciting superior antitumor protection and improving therapeutic outcomes in melanoma‐challenged mice with fewer side effects when combined with αPD‐1.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202400630