Living-Neuron-Based Autogenerator

We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain s...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2023-08, Vol.23 (16), p.7016
Main Authors: Gerasimova, Svetlana A., Beltyukova, Anna, Fedulina, Anastasia, Matveeva, Maria, Lebedeva, Albina V., Pisarchik, Alexander N.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Analysis
Arrays
autogenerator
Brain research
Catecholamines
Cell culture
close-loop control system
Closed loop systems
Control theory
Deep brain stimulation
Feedback
hippocampal slice
hybrid neural circuit
Neural networks
neuron-like oscillator
Neurons
Parkinson's disease
Physiology
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Summary:We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh–Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.
ISSN:1424-8220
1424-8220
DOI:10.3390/s23167016