Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance

Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences physiological plasma VWF clearance. MGL inhibition was...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2022-03, Vol.107 (3), p.668-679
Main Authors: Ward, Soracha E, O'Sullivan, Jamie M, Moran, Alan B, Spencer, Daniel I R, Gardner, Richard A, Sharma, Jyotika, Fazavana, Judicael, Monopoli, Marco, McKinnon, Thomas A J, Chion, Alain, Haberichter, Sandra, O'Donnell, James S
Format: Article
Language:English
Subjects:
Galactose - metabolism
Humans
Lectins - metabolism
Macrophages - metabolism
N-Acetylneuraminic Acid - metabolism
Polysaccharides - metabolism
von Willebrand Factor - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences physiological plasma VWF clearance. MGL inhibition was associated with a significantly extended mean residence time and 3-fold increase in endogenous plasma VWF antigen levels (P
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2020.274720