Transition in vaginal Lactobacillus species during pregnancy and prediction of preterm birth in Korean women
The predominance of vaginal Lactobacillus species, specifically L. crispatus , is important for pregnancy maintenance, but varies by race. The composition of the vaginal microbiome can affect susceptibility to adverse pregnancy outcomes. We performed 16S rRNA gene amplicon sequencing on vaginal swab...
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Published in: | Scientific reports 2022-12, Vol.12 (1), p.22303-22303, Article 22303 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The predominance of vaginal
Lactobacillus
species, specifically
L. crispatus
, is important for pregnancy maintenance, but varies by race. The composition of the vaginal microbiome can affect susceptibility to adverse pregnancy outcomes. We performed 16S rRNA gene amplicon sequencing on vaginal swabs taken from Korean pregnant women. Here, we report the transition of
Lactobacillus
spp. in samples of full-term birth (FTB) collected longitudinally in the second and third trimesters of pregnancy in a cohort study (n = 23) and their association with
Lactobacillus
abundance and preterm birth (PTB) in a case–control study (n = 200).
Lactobacillus
species, which was dominant in FTB samples including those that received interventions in the second trimester, did not change until 37 weeks of gestation. However,
L. crispatus
was replaced by other
Lactobacillus
species after 37 weeks. The PTB risk showed a closer association with the
Lactobacillus
abundance than with community state type determined by
Lactobacillus
species. PTB was associated with less than 90% of
Lactobacillus
abundance and an increase in
Ureplasma parvum
in the second trimester. Thus, the vaginal microbiome may change in preparation for childbirth in response to multiple intrinsic factors after 37 weeks of gestation. Monitoring the
Lactobacillus
abundance may help improve the reliability of microbial PTB biomarkers. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-022-26058-5 |