Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon

Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative str...

Full description

Saved in:
Bibliographic Details
Published in:Advances in hematology 2020, Vol.2020 (2020), p.1-7
Main Authors: Moor Ama, Vicky Jocelyne, Yanou-Njintang, Nicolas, Chetcha, Bernard, Nya Biapa, Prosper Cabral, Kubong, Landry Nguepnkep, Pieme, Anatole Constant
Format: Article
Language:English
Subjects:
Antioxidants
Cholesterol
Diabetes
Free radicals
Genetic disorders
Guardians
Hospitals
Lipid peroxidation
Lipids
Lipoproteins
Males
Mutation
Oxidation
Oxidative stress
Plasma
Sickle cell anemia
Sickle cell disease
Software
Triglycerides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017. After informed consent through the signature of a consent form was obtained, the plasma was collected to determine the lipid profile while the lysate solution of RBC was used to explore some markers of oxidative stress using spectrophotometric methods. Results. Among the 85 patients included in our study, the mean age was 30 ± 5 years and the female to male ratio was 0.97. The majority of the patients (52–81%) had dyslipidaemia, and 22.4% of the patients demonstrated a higher level of atherogenic index of plasma. The patients with a higher level of total cholesterol (TC) (>240 mg/dl) and low-density lipoprotein (LDL-C) (>159 mg/dl) had at least 1,334 fold of malondialdeheyde (MDA) concentration than those with normal level. Also in the same patients, the higher atherogenic plasmatic index (API) significantly (p
ISSN:1687-9104
1687-9112
DOI:10.1155/2020/9864371