The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been seen as key events in CRC progression. In this study we comprehensively evaluate differential...

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Bibliographic Details
Published in:Journal of translational medicine 2018-07, Vol.16 (1), p.191-191, Article 191
Main Authors: Pellatt, Andrew J, Mullany, Lila E, Herrick, Jennifer S, Sakoda, Lori C, Wolff, Roger K, Samowitz, Wade S, Slattery, Martha L
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Apoptosis
Cell growth
Cell Line, Tumor
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Cytokines
Disease
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Growth factors
Humans
Kinases
Male
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miRNA
mRNA
Phenotypes
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal transduction
Signal Transduction - genetics
Statistics, Nonparametric
Stem cells
Studies
TGFβ
Transforming Growth Factor beta - metabolism
Tumorigenesis
Tumors
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Summary:The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been seen as key events in CRC progression. In this study we comprehensively evaluate differential gene expression (RNASeq) of 81 genes in the TGFβ-signaling pathway and evaluate how dysregulated genes are associated with miRNA expression (Agilent Human miRNA Microarray V19.0). We utilize paired carcinoma and normal tissue from 217 CRC cases. We evaluate the associations between differentially expressed genes and miRNAs and sex, age, disease stage, and survival months. Thirteen genes were significantly downregulated and 14 were significantly upregulated after considering fold change (FC) of > 1.50 or 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-018-1566-8