Functional coupling between CA3 and laterobasal amygdala supports schema dependent memory formation

The medial temporal lobe drives semantic congruence dependent memory formation. However, the exact roles of hippocampal subfields and surrounding brain regions remain unclear. Here, we used an established paradigm and high-resolution functional magnetic resonance imaging of the medial temporal lobe...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2021-12, Vol.244, p.118563-118563, Article 118563
Main Authors: Yousuf, Mushfa, Packard, Pau A., Fuentemilla, Lluís, Bunzeck, Nico
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Aging
Amygdala
Amygdala - diagnostic imaging
Brain architecture
Brain mapping
CA3 Region, Hippocampal - diagnostic imaging
Congruence effect
Cortex (entorhinal)
Dentate gyrus
Entorhinal Cortex - diagnostic imaging
Female
Functional magnetic resonance imaging
Hippocampus
Hippocampus - diagnostic imaging
Humans
Learning
Magnetic Resonance Imaging
Male
Medial temporal lobe
Memory
Memory, Long-Term - physiology
Middle Aged
Neural networks
Neuroimaging
Older people
Schema
Semantics
Subfields
Subiculum
Temporal lobe
Temporal Lobe - diagnostic imaging
Young Adult
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Summary:The medial temporal lobe drives semantic congruence dependent memory formation. However, the exact roles of hippocampal subfields and surrounding brain regions remain unclear. Here, we used an established paradigm and high-resolution functional magnetic resonance imaging of the medial temporal lobe together with cytoarchitectonic probability estimates in healthy humans. Behaviorally, robust congruence effects emerged in young and older adults, indicating that schema dependent learning is unimpaired during healthy aging. Within the medial temporal lobe, semantic congruence was associated with hemodynamic activity in the subiculum, CA1, CA3 and dentate gyrus, as well as the entorhinal cortex and laterobasal amygdala. Importantly, a subsequent memory analysis showed increased activity for later remembered vs. later forgotten congruent items specifically within CA3, and this subfield showed enhanced functional connectivity to the laterobasal amygdala. As such, our findings extend current models on schema dependent learning by pinpointing the functional properties of subregions within the medial temporal lobe.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2021.118563