Development of pectin nanoparticles through mechanical homogenization for dissolution enhancement of itraconazole

A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared by a mechanical homogenization using pectin as emulsifier. After freeze-drying, the morphology, crystallinity state,...

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Bibliographic Details
Published in:Asian journal of pharmceutical sciences 2016-06, Vol.11 (3), p.365-375
Main Authors: Burapapadh, Kanokporn, Takeuchi, Hirofumi, Sriamornsak, Pornsak
Format: Article
Language:English
Subjects:
Itraconazole
Nanoparticles
Pectin
Poorly water-soluble drug
Stability
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Summary:A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared by a mechanical homogenization using pectin as emulsifier. After freeze-drying, the morphology, crystallinity state, thermal properties, drug dissolution and stability of the obtained pectin nanoparticles were characterized. The results demonstrated that the morphology of freeze-dried products was different, depending on the type of internal phase; the nanoparticles prepared from chloroform-based nanoemulsions were completely dried and provided a fragile characteristic. The pectin nanoparticles also demonstrated good properties in terms of redispersibility, thermal properties, drug crystallinity and dissolution. The ITZ-loaded pectin nanoparticles showed high percentage of drug dissolved (about 60–80% within 2 h), and maintained their good dissolution properties even after 1-year storage. The results suggested that freeze-dried pectin nanoparticles prepared from nanoemulsions could be used as an effective carrier for enhancement of ITZ dissolution.
ISSN:1818-0876
2221-285X
DOI:10.1016/j.ajps.2015.07.003