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Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29

Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the side effects and the emergence of drug resistance, the search for new anticance...

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Bibliographic Details
Published in:Foods 2020-03, Vol.9 (3), p.300
Main Authors: Zbakh, Hanaa, Zubía, Eva, Reyes, Carolina De Los, Calderón-Montaño, José M, Motilva, Virginia
Format: Article
Language:English
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Summary:Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the side effects and the emergence of drug resistance, the search for new anticancer agents, pharmacologically safe and effective, is needed. In the present study, we have investigated the anticancer effects of eight algal meroterpenoids (AMTs, ) isolated from the brown seaweed and their underlying mechanisms of action using HT-29, a highly metastatic human colon cancer cell line. All the tested meroterpenoids inhibited the growth of HT-29 malignant cells and were less toxic towards non-cancer colon cells, with the AMTs and exhibiting selectivity indexes of 5.26 and 5.23, respectively. Treatment of HT-29 cells with the AMTs , , , , , and induced cell cycle arrest in G2/M phase and, in some instances, apoptosis (compounds , , and ). Compounds - also exhibited significant inhibitory effects on the migration and/or invasion of colon cancer cells. Mechanistic analysis demonstrated that the AMTs , , , , , and reduced phosphorylation levels of extracellular signal‑regulated kinase (ERK) and the AMTs , , , , , and decreased phosphorylation of c‑JUN N‑terminal kinase (JNK). Moreover, the AMTs , , , , , and inhibited phosphorylation levels of protein kinase B (AKT) in colon carcinoma cells. These results provide new insights into the mechanisms and functions of the meroterpenoids of , which exhibit an anticancer effect on HT-29 colon cancer cells by inducing cell cycle arrest and apoptosis via the downregulation of ERK/JNK/AKT signaling pathways.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods9030300