The Impact of Controlled Ovarian Stimulation on Serum Oxidative Stress Markers in Infertile Women with Endometriosis Undergoing ICSI

Endometriosis-related infertility is associated with oxidative stress (OS). The present study aims to compare serum OS markers of infertile women with endometriosis and controls during the follicular phase of the natural cycle (D1), after pituitary downregulation using a GnRH agonist (D2), after con...

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Bibliographic Details
Published in:Antioxidants 2022-06, Vol.11 (6), p.1161
Main Authors: Da Broi, Michele Gomes, Ferreira, Elisa Melo, Andrade, Aline Zyman, Jordão, Alceu Afonso, Ferriani, Rui Alberto, Navarro, Paula Andrea
Format: Article
Language:English
Subjects:
Antioxidants
Birth control
Chorionic gonadotropin
Embryos
Endometriosis
Gonadotropin-releasing hormone
Gonadotropins
Infertility
Inflammatory diseases
Menstruation
ovarian stimulation
Ovaries
Oxidative stress
Patients
Pituitary
Pituitary (anterior)
serum
Ultrasonic imaging
Womens health
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Summary:Endometriosis-related infertility is associated with oxidative stress (OS). The present study aims to compare serum OS markers of infertile women with endometriosis and controls during the follicular phase of the natural cycle (D1), after pituitary downregulation using a GnRH agonist (D2), after controlled ovarian stimulation (COS) on the day of human chorionic gonadotropin administration (D3), and on the day of oocyte retrieval (D4). One hundred and eight serum samples (58 controls and 35 early and 18 advanced endometriosis cases) were collected at these four timepoints. OS markers were compared among the groups and timepoints using a linear regression model with mixed effects and a post-test using orthogonal contrasts. The significance was set at 5%. We observed altered OS markers in the endometriosis patients during the D1, D2, D3, and D4 timepoints compared to the controls. The evidence of systemic OS in infertile patients with endometriosis during COS suggests the mobilization of potent antioxidants in an attempt to protect the oocyte from oxidative damage, especially on the day of oocyte retrieval.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11061161