Serotonin in the regulation of systemic energy metabolism

Serotonin is a well‐known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been discovered; they exist universally in our body and enable diverse biological functions in different organs. Central serotonin regulates mood a...

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Bibliographic Details
Published in:Journal of diabetes investigation 2022-10, Vol.13 (10), p.1639-1645
Main Authors: Moon, Joon Ho, Oh, Chang‐Myung, Kim, Hail
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissue
Amino acids
Animal models
Appetite
Blood platelets
Body fat
Breastfeeding & lactation
Cell growth
Drug development
Energy balance
Energy metabolism
Fatty liver
Fenfluramine
Gene expression
Growth hormones
Insulin resistance
Ligands
Metabolic disorders
Metabolism
Mini Review
Nervous system
Oxidative stress
Pancreas
Phosphorylation
Pregnancy
Proteins
Serotonin
Serotonin receptors
Sibutramine
Steatosis
Therapeutic targets
Thermogenesis
Tryptophan
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Summary:Serotonin is a well‐known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been discovered; they exist universally in our body and enable diverse biological functions in different organs. Central serotonin regulates mood and behavior, and impacts the systemic energy balance by decreasing appetite. A number of drugs that modulate central serotonin function (e.g., fenfluramine, sibutramine and lorcaserin) were approved and used as anti‐obesity drugs, but then later withdrawn due to adverse cardiovascular and carcinogenic effects. Over the past decade, the role of peripheral serotonin in regulating systemic energy metabolism has been extensively explored using tissue‐specific knockout animal models. By inhibiting the action of serotonin in liver and adipose tissues, hepatic steatosis was improved and lipid accumulation was mitigated, respectively. Recent findings show that modulation of the serotonergic system is a promising therapeutic target for metabolic diseases. This review summarizes the role of serotonin in regulating energy metabolism in different organs, and discusses the potential of serotonin modulation for treating metabolic diseases. Serotonin is synthesized in different organs and regulates systemic energy metabolism in auto/para/endocrine manner. Inhibiting the action of serotonin in liver and adipose tissues may be a promising therapeutic approach for metabolic diseases.
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.13879