Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia: A Pilot Study

Objective. To evaluate leukocyte gene expression for 9 selected genes (mRNAs) as biological markers in patients with medication refractory depression before and after treatment with ECT or isoflurane anesthesia (ISO). Methods. In a substudy of a nonrandomized open-label trial comparing effects of EC...

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Bibliographic Details
Published in:Depression Research and Treatment 2014, Vol.2014 (2014), p.k1-12
Main Authors: Iacob, Eli, Tadler, Scott, Light, K. C., Weeks, H. R., Smith, K. W., White, Andrea T., Hughen, R. W., VanHaitsma, T. A., Bushnell, L. A., Light, Alan R.
Format: Article
Language:English
Subjects:
Anesthesiology
Biomarkers
Chronic fatigue syndrome
Cognitive ability
Electroconvulsive therapy
Gene expression
Health sciences
Memory
Mental depression
Metabolism
Studies
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Summary:Objective. To evaluate leukocyte gene expression for 9 selected genes (mRNAs) as biological markers in patients with medication refractory depression before and after treatment with ECT or isoflurane anesthesia (ISO). Methods. In a substudy of a nonrandomized open-label trial comparing effects of ECT to ISO therapy, blood samples were obtained before and after treatment from 22 patients with refractory depression, and leukocyte mRNA was assessed by quantitative PCR. Patients’ mRNAs were also compared to 17 healthy controls. Results. Relative to controls, patients before treatment showed significantly higher IL10 and DBI and lower ADRA2A and ASIC3 mRNA (P
ISSN:2090-1321
2090-133X
DOI:10.1155/2014/582380