Exploring the impact of biological alterations in the superior thalamic radiations on exploratory eye movements in attenuated psychosis syndrome

• Published in: Frontiers in psychiatry 2024-06, Vol.15, p.1323786
• Main Authors: Arai, Yu, Katagiri, Naoyuki, Tagata, Hiromi, Uchino, Takashi, Saito, Junichi, Shido, Yusuke, Kamiya, Kouhei, Hori, Masaaki, Mizuno, Masafumi, Nemoto, Takahiro
• Format: Article
• Language: English
• Subjects: attenuated psychosis syndrome; diffusion tensor imaging; exploratory eye movement; fixations; Psychiatry; scan path lengths; superior thalamic radiation
• ISSN: 1664-0640; 1664-0640
• DOI: 10.3389/fpsyt.2024.1323786

Aberrant fixation and scan paths in visual searches have been repeatedly reported in schizophrenia. The frontal eye fields (FEF) and thalamus may be responsible for fixation and scan paths. These two regions are connected by superior thalamic radiation (STR) in humans. Studies have reported reduced fixation numbers and shortened scan path lengths in individuals with attenuated psychosis syndrome (APS) and schizophrenia. In this study, we hypothesized that STRs in the white matter fiber bundles of impairments underlie abnormalities in fixation and scan path length in individuals with APS. Twenty-one individuals with APS and 30 healthy controls participated in this study. All participants underwent diffusion tensor imaging, and fractional anisotropy (FA) values of the left and right STR were analyzed using the novel method TractSeg. The number of eye fixations (NEF), total eye scanning length (TESL), and mean eye scanning length (MESL), derived using the exploratory eye movement (EEM) test, were adopted to evaluate the fixation and scan path length. We compared the FA values of the bilateral STR and EEM parameters between the APS and healthy control groups. We investigated the correlation between bilateral STR and EEM parameters in the APS and healthy control groups. NEF, TESL, MESL, and the FA values of the left STR were significantly reduced in individuals with APS compared to healthy controls. The left STR FA value in the APS group was significantly positively correlated with the MESL ( = 0.567, = 0.007). In addition, the right STR FA value of the APS group was significantly correlated with the TESL ( = 0.587, = 0.005) and MESL ( = 0.756,  = 0.7×10 ). These results demonstrate that biological changes in the STR, which connects the thalamus and FEF, underlie abnormalities in fixation and scanning. Recently, aberrations in the thalamus-frontal connection have been shown to underlie the emergence of psychotic symptoms. STR impairment may be a part of the biological basis of APS in individuals with subthreshold psychotic symptoms.