Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms

Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which aff...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-07, Vol.12 (7), p.1772
Main Authors: Wong, Lai-San, Yen, Yu-Ta
Format: Article
Language:English
Subjects:
Autoimmune diseases
Care and treatment
Complications and side effects
Connective tissue diseases
Dermatitis
Development and progression
Diagnosis
Lupus
Nervous system
Pathogenesis
Pathophysiology
Patients
Pruritus
Quality of life
Review
small fiber neuropathy
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Summary:Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which affect their quality of life. However, it is rarely recognized both by patients and physicians. Meanwhile, pruritus is not only a symptom but is also related to the disease severity of some ACTDs. The pathophysiology of ACTD related pruritus is ambiguous. This review summarizes the features and possible mechanisms of ACTD-related pruritus, which might lead to proper diagnosis and treatment.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12071772