Prevalence of vitamin B12 deficiency and its association with metformin-treated type 2 diabetic patients: A cross sectional study

Metformin is the most-used drug in type 2 diabetes mellitus (T2DM) management, but it may lower B12 status as a use consequence. However, few studies in Saudi Arabia have assessed this risk. This study aimed to estimate the prevalence of vitamin B12 deficiency in metformin-treated type 2 diabetic pa...

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Bibliographic Details
Published in:Human nutrition & metabolism 2022-03, Vol.27, p.200138, Article 200138
Main Authors: Almatrafi, Shaimaa B., Bakr, El-Sayed H., Almatrafi, Asem A., Altayeb, Manal M.
Format: Article
Language:English
Subjects:
Metformin
Type 2 diabetes mellitus
Vitamin B12 dietary intake
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Summary:Metformin is the most-used drug in type 2 diabetes mellitus (T2DM) management, but it may lower B12 status as a use consequence. However, few studies in Saudi Arabia have assessed this risk. This study aimed to estimate the prevalence of vitamin B12 deficiency in metformin-treated type 2 diabetic patients and its association with drug duration and dose with relation to B12 dietary intake. A cross sectional study was conducted with 206 patients with type 2 diabetic patients using metformin for 6 months or more and attending the diabetic clinics at Al-Noor Specialist Hospital in Holy Makkah. Serum B12 levels were estimated, and biochemical B12 deficiency was defined as serum levels
ISSN:2666-1497
2666-1497
DOI:10.1016/j.hnm.2022.200138