Topographical Analysis of Aneurysm Wall Enhancement With 3-Dimensional Mapping

Aneurysm wall enhancement has been identified as a potential biomarker for aneurysm instability. Enhancement has been determined by different approaches on 2D multiplanar views. This study describes a new method to quantify enhancement through 3D heatmaps and histograms. A custom algorithm was devel...

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Bibliographic Details
Published in:Stroke: vascular and interventional neurology 2022-07, Vol.2 (4)
Main Authors: Raghuram, Ashrita, Varon, Alberto, Sanchez, Sebastian, Ishii, Daizo, Wu, Chaorong, Magnotta, Vincent A, Hasan, David M, Koscik, Timothy R, Samaniego, Edgar A
Format: Article
Language:English
Subjects:
aneurysm
Aneurysms
mapping
MRI
wall enhancement
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Summary:Aneurysm wall enhancement has been identified as a potential biomarker for aneurysm instability. Enhancement has been determined by different approaches on 2D multiplanar views. This study describes a new method to quantify enhancement through 3D heatmaps and histograms. A custom algorithm was developed using orthogonal probes extending from the aneurysm lumen into the wall to create 3D heatmaps and histograms of wall enhancement on 7T-MRI. Three quantitative metrics for general, specific, and focal wall enhancement were generated from the histograms. Thirty-two aneurysms were analyzed and classified based on 3D heatmaps and histograms. Larger aneurysms were more enhancing (Spearman's r=0.472, p=0.006), and had more heterogeneous enhancement (Spearman's r=0.557, p
ISSN:2694-5746
2694-5746
DOI:10.1161/SVIN.121.000309