Rapamycin Prevents the Development and Progression of Mutant Epidermal Growth Factor Receptor Lung Tumors with the Acquired Resistance Mutation T790M

• Published in: Cell reports (Cambridge) 2014-06, Vol.7 (6), p.1824-1832
• Main Authors: Kawabata, Shigeru, Mercado-Matos, José R., Hollander, M. Christine, Donahue, Danielle, Wilson, Willie, Regales, Lucia, Butaney, Mohit, Pao, William, Wong, Kwok-Kin, Jänne, Pasi A., Dennis, Phillip A.
• Format: Article
• Language: English
• Subjects: Animals; Antibiotics, Antineoplastic - pharmacology; Disease Progression; Drug Resistance, Neoplasm; Humans; Lung Neoplasms - enzymology; Lung Neoplasms - genetics; Lung Neoplasms - prevention & control; Mice; Molecular Sequence Data; Mutation; Random Allocation; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Sirolimus - pharmacology; TOR Serine-Threonine Kinases - metabolism
• ISSN: 2211-1247; 2211-1247
• DOI: 10.1016/j.celrep.2014.05.039

Lung cancer in never-smokers is an important disease often characterized by mutations in epidermal growth factor receptor (EGFR), yet risk reduction measures and effective chemopreventive strategies have not been established. We identify mammalian target of rapamycin (mTOR) as potentially valuable target for EGFR mutant lung cancer. mTOR is activated in human lung cancers with EGFR mutations, and this increases with acquisition of T790M mutation. In a mouse model of EGFR mutant lung cancer, mTOR activation is an early event. As a single agent, the mTOR inhibitor rapamycin prevents tumor development, prolongs overall survival, and improves outcomes after treatment with an irreversible EGFR tyrosine kinase inhibitor (TKI). These studies support clinical testing of mTOR inhibitors in order to prevent the development and progression of EGFR mutant lung cancers. [Display omitted] •mTOR activation is detected in human lung cancers with EGFR mutations•mTOR activation is an early event in a mouse model of EGFR mutant lung cancer•Rapamycin prevents growth of EGFR T790M mutant tumors and prolongs overall survival•Rapamycin improves progression-free and overall survival after EGFR TKI treatment Lung cancer in never-smokers is often characterized by mutations in EGFR. Kawabata et al. report that mTOR activation is detected in human lung cancers with EGFR mutations and is an early event in a mouse model of EGFR mutant lung cancer. The mTOR inhibitor rapamycin prevented the growth of T790M mutant tumors and prolonged overall survival in this mouse model. In addition, rapamycin prolonged disease-free and overall survival of mice that completed treatment with an irreversible inhibitor of EGFR.