Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow's Milk Protein Allergy

Cow's milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or "dys...

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Published in:International journal of molecular sciences 2023-06, Vol.24 (12), p.9781
Main Authors: Cela, Ludovica, Brindisi, Giulia, Gravina, Alessandro, Pastore, Francesca, Semeraro, Antonio, Bringheli, Ivana, Marchetti, Lavinia, Morelli, Rebecca, Cinicola, Bianca, Capponi, Martina, Gori, Alessandra, Pignataro, Elia, Piccioni, Maria Grazia, Zicari, Anna Maria, Anania, Caterina
Format: Article
Language:English
Subjects:
Allergens
Allergies
Animals
Antigens
Autoimmune diseases
B cells
Breastfeeding & lactation
Cattle
children
Cow's milk
cow’s milk protein allergy (CMPA)
Cytokines
Diet
Dysbacteriosis
Female
Food
Food allergies
Food allergy
Food Hypersensitivity
Gastrointestinal Microbiome
Hypotheses
Immune response
Immune system
Immune Tolerance
Immunoglobulins
Immunological tolerance
Inflammation
Intestinal microflora
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Milk
Milk Hypersensitivity - therapy
Milk Proteins
Molecular modelling
Pathogens
pediatric
Pediatrics
Probiotics
Probiotics - therapeutic use
Proteins
Review
Tumor necrosis factor-TNF
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creator Cela, Ludovica
Brindisi, Giulia
Gravina, Alessandro
Pastore, Francesca
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Capponi, Martina
Gori, Alessandra
Pignataro, Elia
Piccioni, Maria Grazia
Zicari, Anna Maria
Anania, Caterina
description Cow's milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or "dysbiosis". Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics' efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms.
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subjects Allergens
Allergies
Animals
Antigens
Autoimmune diseases
B cells
Breastfeeding & lactation
Cattle
children
Cow's milk
cow’s milk protein allergy (CMPA)
Cytokines
Diet
Dysbacteriosis
Female
Food
Food allergies
Food allergy
Food Hypersensitivity
Gastrointestinal Microbiome
Hypotheses
Immune response
Immune system
Immune Tolerance
Immunoglobulins
Immunological tolerance
Inflammation
Intestinal microflora
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Milk
Milk Hypersensitivity - therapy
Milk Proteins
Molecular modelling
Pathogens
pediatric
Pediatrics
Probiotics
Probiotics - therapeutic use
Proteins
Review
Tumor necrosis factor-TNF
title Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow's Milk Protein Allergy
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