Perinatal outcomes of re-recurrent gestational diabetes mellitus and their prognostic factors: A retrospective cohort study in China

• Published in: Chinese medical journal 2024-02, Vol.137 (4), p.499-501
• Main Authors: Xu, Xia, Guo, Yanni, Liao, Tingting, Zhang, Huale, Jiang, Rumeng, Huang, Shuyao, Yan, Jianying
• Format: Article
• Language: English
• Subjects: Body mass index; Cohort analysis; Correspondence; Diabetes, Gestational - diagnosis; Female; Gestational age; Gestational diabetes; Glucose; Humans; Hypothyroidism; Insulin resistance; Maternal Age; Pregnancy; Pregnancy Outcome; Prognosis; Retrospective Studies; Risk factors; Software; Thyroid gland; Women
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/CM9.0000000000002802

Currently, studies on perinatal outcomes of women with re-recurrent GDM and their prognostic factors are very rare. [...]this retrospective cohort study was performed to explore perinatal outcomes of pregnant woman with re-recurrent GDM and their prognostic factors. Between recurrent group (n = 37) and re-recurrent group (n = 65), there was no statistically significant difference in all baseline characteristics, including maternal age (years) (33.5 ± 3.4 vs. 33.7 ± 2.9), qualifications (upgraduate, 61.5% [40/65] vs. 78.4% [29/37]), mode of conception (natural conception, 96.9% [63/65] vs. 97.3% [36/27]), family history of diabetes (12.3% [8/65] vs. 8.1% [3/37]), gravidity (4.0 [3.0–5.0] vs. 4.0 [3.0–5.0]), macrosomia history (10.8% [7/65] vs. 8.1% [3/37]), preterm history (7.7% [5/65] vs. 13.5% [5/37]), and gestational weight gain (kg) (13.6 ± 3.6 vs. 15.0 ± 4.6) except pre-pregnancy body mass index (BMI) (kg/m2) (23.5 [22.0–24.9]) vs. [...]the relationship between hypothyroidism and GDM is still controversial. In order to further demonstrate the role of inter-pregnancy interval and BMI gain between the pregnancies, the authors calculated two scenarios with fixed information and different combinations of the main risk factors.