The Modulating Effect of Dietary Beta-Glucan Supplementation on Expression of Immune Response Genes of Broilers during a Coccidiosis Challenge

This study investigated the effects of a yeast-derived β-glucan (Auxoferm YGT) supplementation on mRNA expression of immune response genes in the spleen, thymus, and bursa of broiler chickens during a mixed infection. Day (d)-old chicks ( = 1440) were fed diets containing 0% or 0.1% YGT. On d 8 post...

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Bibliographic Details
Published in:Animals (Basel) 2021-01, Vol.11 (1), p.159
Main Authors: Omara, Islam I, Pender, Chasity M, White, Mallory B, Dalloul, Rami A
Format: Article
Language:English
Subjects:
Birds
broiler
Chickens
Chicks
Coccidiosis
cytokine
Cytokines
Diet
Eimeria
Gene expression
Genes
Glucan
Immune response
Immune system
immunity
Infections
Inoculum
Interferon
Interleukin 10
Macrophage migration inhibitory factor
Nitric oxide
Nitric-oxide synthase
Parasitic diseases
Pathogens
Poultry
Software
Spleen
Statistical analysis
Thymus
Thymus gland
Tissues
Yeast
Yeasts
β-Glucan
γ-Interferon
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Summary:This study investigated the effects of a yeast-derived β-glucan (Auxoferm YGT) supplementation on mRNA expression of immune response genes in the spleen, thymus, and bursa of broiler chickens during a mixed infection. Day (d)-old chicks ( = 1440) were fed diets containing 0% or 0.1% YGT. On d 8 post-hatch, half the replicate pens ( = 8) were challenged with a mixed inoculum of , , and . On d 10 and d 14 post-hatch, the spleen, thymus, and bursa were collected to evaluate mRNA abundance by quantitative real-time PCR. Data were analyzed using PROC GLIMMIX model (2-way interaction) and differences were established by LS-MEANS with significance reported at ≤ 0.05. In spleen tissues at d 10, expression of interleukin (IL)-10 and inducible nitric oxide synthase (iNOS) were elevated in both 0.1% YGT-fed challenged and non-challenged birds. In thymus tissues at d 14, expression of IL-10, IL-17F, interferon (IFN)-γ, iNOS, and macrophage migration inhibitory factor (MIF) were elevated in challenged birds fed 0.1% YGT. In bursal tissues at d 10 and d 14, expression of IL-10, IFN-γ, iNOS (d 10 only), and MIF were elevated in 0.1% YGT-fed challenged and non-challenged birds. Dietary β-glucan supplementation to chicken diets modulated their immune response to the challenge.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani11010159