Synthesis, physicochemical properties and antimicrobial activity of a di-aminopropionic acid hydrogen tri-iodide coordination compound

• Published in: BMC research notes 2024-12, Vol.17 (1), p.384-11, Article 384
• Main Authors: Turganbay, Seitzhan, Kenesheva, Sabina, Jumagaziyeva, Аrdak, Ilin, Alexandr, Askarova, Dana, Azembayev, Amir, Kurmanaliyeva, Assel
• Format: Article
• Language: English
• Subjects: Acinetobacter baumannii - drug effects; Alanine; Amino acids; Ampicillin; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotics; Antimicrobial activity, multidrug resistance; Calorimetry; Calorimetry, Differential Scanning; Communicable diseases; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Coordination compound; Drug resistance in microorganisms; Escherichia coli; Escherichia coli - drug effects; Gram-Negative Bacteria - drug effects; Hydrogen; Iodides - chemistry; Iodides - pharmacology; Iodine; Microbial Sensitivity Tests; Propionates - chemical synthesis; Propionates - chemistry; Propionates - pharmacology; Pseudomonas aeruginosa - drug effects; Research Note; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus - drug effects; Thermal properties
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-024-07052-8

The objective of this study is to synthesize and comprehensively characterize a novel iodine-containing coordination compound, di-aminopropionic acid hydrogen tri-iodide. This involves determining its structural, physicochemical, and thermal properties, as well as evaluating its antimicrobial activity against a range of bacterial strains, including multidrug-resistant pathogens. The aim is to explore the potential of this compound as a candidate for developing new antibacterial agents to address the challenge of antibiotic resistance. An original iodine-containing semiorganic coordination compound was synthesized and characterized. The physicochemical properties were studied via diffraction, FTIR spectroscopy and thermogravimetric/differential scanning calorimetry (TG/DSC). In vitro antimicrobial activity evaluation was performed using two-fold serial dilution method. The obtained results demonstrated efficiency against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii) bacteria including MDR strains that cause infectious disease. The results of the antibacterial evaluation revealed that the new iodine coordination compound - di-aminopropionic acid hydrogen tri-iodide possesses high bactericidal properties and exhibits better antimicrobial activity against both susceptible and multidrug-resistant strains than does Lugol solution and ampicillin sodium, which are used as reference drugs.