Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses

Pigs/bovines share with humans some of the antigens present on cardiac valves. Two such antigens are: the major xenogenic Ag, “Gal” present in all pig/bovine very close to human B-antigen of ABO-blood-group system; the minor Ag, pig histo-blood-group AH-antigen identical to human AH-antigen and pres...

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Bibliographic Details
Published in:EBioMedicine 2019-04, Vol.42, p.54-63
Main Authors: Schussler, O., Lila, N., Perneger, T., Mootoosamy, P., Grau, J., Francois, A., Smadja, D.M., Lecarpentier, Y., Ruel, M., Carpentier, A.
Format: Article
Language:English
Subjects:
Human health and pathology
Life Sciences
Research paper
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Summary:Pigs/bovines share with humans some of the antigens present on cardiac valves. Two such antigens are: the major xenogenic Ag, “Gal” present in all pig/bovine very close to human B-antigen of ABO-blood-group system; the minor Ag, pig histo-blood-group AH-antigen identical to human AH-antigen and present by some animals. We hypothesize that these antigens may modify the immunogenicity of the bioprosthesis and also its longevity. ABO distribution may vary between patients with low (
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2019.02.047