Localization of post-transplant lymphoproliferative disorders to the stomach might be associated with favorable outcome : a systematic review

• Published in: Saudi journal of kidney diseases and transplantation 2014-03, Vol.25 (2), p.353-361
• Main Authors: Amini, Muhsin, Qamar Chehreh, Muhammad Ibrahim, Taheri, Said, Agha, Shahram, Khedmat, Husayn
• Format: Article
• Language: English
• Subjects: Adult; Antibodies, Monoclonal, Murine-Derived - therapeutic use; Chemotherapy; Comorbidity; Complications; Female; Humans; Immunologic Factors - therapeutic use; Kidney Transplantation - adverse effects; Kidneys; Localization; Lymphocytes; Lymphoproliferative disorders; Lymphoproliferative Disorders - etiology; Lymphoproliferative Disorders - mortality; Lymphoproliferative Disorders - therapy; Male; Medical prognosis; Metastasis; Middle Aged; Mortality; Neoplasm Metastasis; Patient outcomes; Physiological aspects; Prognosis; Rituximab; Stomach; Stomach diseases; Stomach Diseases - mortality; Stomach Diseases - therapy; Studies; Survival Analysis; Transplantation; Transplants & implants; Treatment Outcome; Young Adult; الأمراض; الاضطرابات التكاثرية اللمفية; الكلى; المرضى; المضاعفات; المعدة; زرع الأعضاء
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.128543

Gastric localization of post-transplant lymphoproliferative disorders (PTLDs) is very rare. In this study, we aimed to accumulate existing data in the current literature to reveal the clinical, histopathological and prognostic specificities associated with gastric PTLDs and to find the best treatment strategies in this patient population. A comprehensive search was conducted for the available data in the current literature using Pubmed and Google scholar search engines for reports on gastric PTLD in renal transplant recipients. Data of different studies were standardized and entered into a database and analyzed. No statistically significant difference was found between gastric and non-gastric PTLD. Gastric PTLD was relatively more prevalent in female patients (P = 0.08) and showed a trend toward better outcome (P = 0.1) and less metastasis (P = 0.07). Surgical intervention and rituximab therapy were associated with a more favorable outcome (17 % mortality). Our study showed that organ transplant recipients having gastric PTLD develop metastasis less frequently and tend to have a relatively more favorable outcome. Prospective studies with larger patient populations are needed to confirm or modify our results.