Short-Term Intravenous Administration of Carbon Nano-Onions is Non-Toxic in Female Mice

A nanoscale drug carrier could have a variety of therapeutic and diagnostic uses provided that the carrier is biocompatible in vivo. Carbon nano-onions (CNOs) have shown promising results as a nanocarrier for drug delivery. However, the systemic effect of CNOs in rodents is unknown. Therefore, we in...

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Bibliographic Details
Published in:International journal of nanomedicine 2023-01, Vol.18, p.3897-3912
Main Authors: Tan, Yi Zhen, Thomsen, Lucy R, Shrestha, Nensi, Camisasca, Adalberto, Giordani, Silvia, Rosengren, Rhonda
Format: Article
Language:English
Subjects:
accumulation
Administration, Intravenous
Animals
Carbon
carbon nano-onions
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dosage and administration
drug carriers
Drug delivery systems
drug metabolism
Drugs
Ethylenediaminetetraacetic acid
Female
Health aspects
Humans
intravenous administration
Liver
Mice
Onions
Original Research
oxidative stress
Physiological aspects
Scientific equipment and supplies industry
Superoxide
toxicity
Vehicles
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Summary:A nanoscale drug carrier could have a variety of therapeutic and diagnostic uses provided that the carrier is biocompatible in vivo. Carbon nano-onions (CNOs) have shown promising results as a nanocarrier for drug delivery. However, the systemic effect of CNOs in rodents is unknown. Therefore, we investigated the toxicity of CNOs following intravenous administration in female BALB/c mice. Single or repeated administration of oxi-CNOs (125, 250 or 500 µg) did not affect mouse behavior or organ weight and there was also no evidence of hepatotoxicity or nephrotoxicity. Histological examination of organ slices revealed a significant dose-dependent accumulation of CNO aggregates in the spleen, liver and lungs (p
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S414438