Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy

Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune response. Met...

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Bibliographic Details
Published in:Molecular cancer 2025-01, Vol.24 (1), p.7-28, Article 7
Main Authors: Huang, Kun, Han, Ying, Chen, Yihong, Shen, Hong, Zeng, Shan, Cai, Changjing
Format: Article
Language:English
Subjects:
Amino acids
Animals
Antimitotic agents
Antineoplastic agents
B cells
Cancer
Cancer therapy
Care and treatment
Cellular Reprogramming
Development and progression
Disease susceptibility
Energy Metabolism
Health aspects
Humans
Immune response
Metabolic Networks and Pathways
Metabolic regulators
Metabolic Reprogramming
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Oncology, Experimental
Physiological aspects
Review
TME
Tumor Microenvironment
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Summary:Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune response. Metabolic dysregulation creates an immunosuppressive TME, impairing the antitumor immune response. In this review, we discuss how metabolic regulators affect the tumor cell and the crosstalk of TME. We also summarize recent clinical trials involving metabolic regulators and the challenges of metabolism-based tumor therapies in clinical translation. In a word, our review distills key regulatory factors and their mechanisms of action from the complex reprogramming of tumor metabolism, identified as tumor metabolic regulators. These regulators provide a theoretical basis and research direction for the development of new strategies and targets in cancer therapy based on tumor metabolic reprogramming.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-024-02205-6