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SCLC-J1, a novel small cell lung cancer cell line
Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusi...
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| Published in: | Biochemistry and biophysics reports 2021-09, Vol.27, p.101089-101089, Article 101089 |
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| Main Authors: | , , , , , , , , , , , , , |
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| container_end_page | 101089 |
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| container_start_page | 101089 |
| container_title | Biochemistry and biophysics reports |
| container_volume | 27 |
| creator | Ohara, Kazuo Kinoshita, Shintaro Ando, Jun Azusawa, Yoko Ishii, Midori Harada, Sakiko Mitsuishi, Yoichiro Asao, Tetsuhiko Tajima, Ken Yamamoto, Taketsugu Takahashi, Fumiyuki Komatsu, Norio Takahashi, Kazuhisa Ando, Miki |
| description | Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusion in a patient with advanced SCLC. SCLC-J1 cells express ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.
These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment.
•A novel small lung cancer cell line, SCLC-J1, was successfully established.•SCLC-J1 cells express the tumor-specific antigens ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.•SCLC-J1 will provide insights into SCLC biology that may permit better therapeutic targeting. |
| doi_str_mv | 10.1016/j.bbrep.2021.101089 |
| format | article |
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These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment.
•A novel small lung cancer cell line, SCLC-J1, was successfully established.•SCLC-J1 cells express the tumor-specific antigens ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.•SCLC-J1 will provide insights into SCLC biology that may permit better therapeutic targeting.</description><identifier>ISSN: 2405-5808</identifier><identifier>EISSN: 2405-5808</identifier><identifier>DOI: 10.1016/j.bbrep.2021.101089</identifier><identifier>PMID: 34381882</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>B7-H3 ; DLL3 ; Established SCLC cell line ; GD2 ; Small cell lung cancer ; Somatic mutations</subject><ispartof>Biochemistry and biophysics reports, 2021-09, Vol.27, p.101089-101089, Article 101089</ispartof><rights>2021 Juntendo University School of Medicine</rights><rights>2021 Juntendo University School of Medicine 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c452t-e287c23261ab28e36926bba661bf4288b164f329bfd6915979ce06cdf9fc7e583</cites><orcidid>0000-0001-5749-4118 ; 0000-0001-8871-1330 ; 0000-0002-9975-2282 ; 0000-0001-7040-6653</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339127/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2405580821001837$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3535,27903,27904,45759,53770,53772</link.rule.ids></links><search><creatorcontrib>Ohara, Kazuo</creatorcontrib><creatorcontrib>Kinoshita, Shintaro</creatorcontrib><creatorcontrib>Ando, Jun</creatorcontrib><creatorcontrib>Azusawa, Yoko</creatorcontrib><creatorcontrib>Ishii, Midori</creatorcontrib><creatorcontrib>Harada, Sakiko</creatorcontrib><creatorcontrib>Mitsuishi, Yoichiro</creatorcontrib><creatorcontrib>Asao, Tetsuhiko</creatorcontrib><creatorcontrib>Tajima, Ken</creatorcontrib><creatorcontrib>Yamamoto, Taketsugu</creatorcontrib><creatorcontrib>Takahashi, Fumiyuki</creatorcontrib><creatorcontrib>Komatsu, Norio</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><creatorcontrib>Ando, Miki</creatorcontrib><title>SCLC-J1, a novel small cell lung cancer cell line</title><title>Biochemistry and biophysics reports</title><description>Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusion in a patient with advanced SCLC. SCLC-J1 cells express ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.
These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment.
•A novel small lung cancer cell line, SCLC-J1, was successfully established.•SCLC-J1 cells express the tumor-specific antigens ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.•SCLC-J1 will provide insights into SCLC biology that may permit better therapeutic targeting.</description><subject>B7-H3</subject><subject>DLL3</subject><subject>Established SCLC cell line</subject><subject>GD2</subject><subject>Small cell lung cancer</subject><subject>Somatic mutations</subject><issn>2405-5808</issn><issn>2405-5808</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kU-P0zAQxS0EYlfLfgIuOXIgxTOO3fEBJFTxZ1ElDsDZcpxJcZUmxU4r7bcn2VRo98LFtp7n_Sy_J8RrkCuQYN7tV3Wd-LhCiTArkuwzcY2V1KUmSc8fna_Ebc57KSVoJI3mpbhSlSIgwmsBPzbbTfkN3ha-6Iczd0U--K4rAk9Ld-p3RfB94HQRYs-vxIvWd5lvL_uN-PX508_N13L7_cvd5uO2DJXGsWSkdUCFBnyNxMpYNHXtjYG6rZCoBlO1Cm3dNsaCtmsbWJrQtLYNa9akbsTdwm0Gv3fHFA8-3bvBR_cgDGnnfBpj6Nix9BJJWRm0qhA8eWrYKl1BC2B5PbE-LKzjqT5wE7gfk--eQJ_e9PG32w1nR0pZwBnw5gJIw58T59EdYp4j8T0Pp-xQG0mKUMppVC2jIQ05J27_PQPSzd25vXvozs3duaW7yfV-cfEU6TlycjlEnpJvYuIwTn-O__X_BX19njs</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Ohara, Kazuo</creator><creator>Kinoshita, Shintaro</creator><creator>Ando, Jun</creator><creator>Azusawa, Yoko</creator><creator>Ishii, Midori</creator><creator>Harada, Sakiko</creator><creator>Mitsuishi, Yoichiro</creator><creator>Asao, Tetsuhiko</creator><creator>Tajima, Ken</creator><creator>Yamamoto, Taketsugu</creator><creator>Takahashi, Fumiyuki</creator><creator>Komatsu, Norio</creator><creator>Takahashi, Kazuhisa</creator><creator>Ando, Miki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5749-4118</orcidid><orcidid>https://orcid.org/0000-0001-8871-1330</orcidid><orcidid>https://orcid.org/0000-0002-9975-2282</orcidid><orcidid>https://orcid.org/0000-0001-7040-6653</orcidid></search><sort><creationdate>20210901</creationdate><title>SCLC-J1, a novel small cell lung cancer cell line</title><author>Ohara, Kazuo ; Kinoshita, Shintaro ; Ando, Jun ; Azusawa, Yoko ; Ishii, Midori ; Harada, Sakiko ; Mitsuishi, Yoichiro ; Asao, Tetsuhiko ; Tajima, Ken ; Yamamoto, Taketsugu ; Takahashi, Fumiyuki ; Komatsu, Norio ; Takahashi, Kazuhisa ; Ando, Miki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-e287c23261ab28e36926bba661bf4288b164f329bfd6915979ce06cdf9fc7e583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>B7-H3</topic><topic>DLL3</topic><topic>Established SCLC cell line</topic><topic>GD2</topic><topic>Small cell lung cancer</topic><topic>Somatic mutations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohara, Kazuo</creatorcontrib><creatorcontrib>Kinoshita, Shintaro</creatorcontrib><creatorcontrib>Ando, Jun</creatorcontrib><creatorcontrib>Azusawa, Yoko</creatorcontrib><creatorcontrib>Ishii, Midori</creatorcontrib><creatorcontrib>Harada, Sakiko</creatorcontrib><creatorcontrib>Mitsuishi, Yoichiro</creatorcontrib><creatorcontrib>Asao, Tetsuhiko</creatorcontrib><creatorcontrib>Tajima, Ken</creatorcontrib><creatorcontrib>Yamamoto, Taketsugu</creatorcontrib><creatorcontrib>Takahashi, Fumiyuki</creatorcontrib><creatorcontrib>Komatsu, Norio</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><creatorcontrib>Ando, Miki</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Biochemistry and biophysics reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohara, Kazuo</au><au>Kinoshita, Shintaro</au><au>Ando, Jun</au><au>Azusawa, Yoko</au><au>Ishii, Midori</au><au>Harada, Sakiko</au><au>Mitsuishi, Yoichiro</au><au>Asao, Tetsuhiko</au><au>Tajima, Ken</au><au>Yamamoto, Taketsugu</au><au>Takahashi, Fumiyuki</au><au>Komatsu, Norio</au><au>Takahashi, Kazuhisa</au><au>Ando, Miki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SCLC-J1, a novel small cell lung cancer cell line</atitle><jtitle>Biochemistry and biophysics reports</jtitle><date>2021-09-01</date><risdate>2021</risdate><volume>27</volume><spage>101089</spage><epage>101089</epage><pages>101089-101089</pages><artnum>101089</artnum><issn>2405-5808</issn><eissn>2405-5808</eissn><abstract>Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine carcinoma. It initially responds to chemotherapy but rapidly becomes chemoresistant and it is highly proliferative. The prognosis in SCLC is poor. We have established a novel SCLC cell line, SCLC-J1, from a malignant pleural effusion in a patient with advanced SCLC. SCLC-J1 cells express ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.
These features of the new SCLC cell line may be useful in understanding the cellular and molecular biology of SCLC and in designing better treatment.
•A novel small lung cancer cell line, SCLC-J1, was successfully established.•SCLC-J1 cells express the tumor-specific antigens ganglioside GD2, CD276, and Delta-like protein 3. RB1 is lost.•SCLC-J1 will provide insights into SCLC biology that may permit better therapeutic targeting.</abstract><pub>Elsevier B.V</pub><pmid>34381882</pmid><doi>10.1016/j.bbrep.2021.101089</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5749-4118</orcidid><orcidid>https://orcid.org/0000-0001-8871-1330</orcidid><orcidid>https://orcid.org/0000-0002-9975-2282</orcidid><orcidid>https://orcid.org/0000-0001-7040-6653</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biochemistry and biophysics reports, 2021-09, Vol.27, p.101089-101089, Article 101089 |
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| source | ScienceDirect; PubMed Central |
| subjects | B7-H3 DLL3 Established SCLC cell line GD2 Small cell lung cancer Somatic mutations |
| title | SCLC-J1, a novel small cell lung cancer cell line |
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