Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children

• Published in: International journal of infectious diseases 2014-12, Vol.29 (C), p.18-23
• Main Authors: Wang, Meijuan, Wang, Yuqing, Yan, Yongdong, Zhu, Canhong, Huang, Li, Shao, Xuejun, Xu, Jun, Zhu, Hong, Sun, Xiangle, Ji, Wei, Chen, Zhengrong
• Format: Article
• Language: English
• Subjects: Bronchoalveolar Lavage Fluid; Child; Child, Preschool; Children; Clinical characteristics; DNA, Bacterial - analysis; Female; Fever - diagnosis; Humans; Infant; Infectious Disease; Interferon-gamma - blood; Length of Stay; Lung - pathology; Male; Mycoplasma pneumoniae - genetics; Mycoplasma pneumoniae - isolation & purification; Pneumonia, Mycoplasma - diagnosis; Pneumonia, Mycoplasma - immunology; Pulmonary/Respiratory; Refractory Mycoplasma pneumoniae pneumonia; Retrospective Studies; Tumor Necrosis Factor-alpha - blood
• ISSN: 1201-9712; 1878-3511
• DOI: 10.1016/j.ijid.2014.07.020

Highlights • The purpose of this study was to explore the clinical and laboratory characterisitcs of children with refractory Mycoplasma pneumoniae pneumonia. • The clinical relevance to refractory Mycoplasma pneumoniae pneumonia is still largely debated all over world. Excessive inflammation maybe play more important role in RMPP than macrolide resistance in China because of high prevalence of macrolide-resistant M. pneumonia. • In present study, Mycoplasma pneumoniae load is closely correlated with neutrophils and disease severity. Inflammatory indicators such as TNF-α and INF-γ also contribute to the progression of refractory Mycoplasma pneumoniae pneumonia. • In conclusion, both Mycoplasma pneumoniae load and excessive inflammation play a role in refractory Mycoplasma pneumoniae pneumonia.