Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01

Four new metabolites, asperchalasine I ( ), dibefurin B ( ) and two epicoccine derivatives ( and ), together with seven known compounds ( - ) were isolated from a mangrove fungus sp. SYSU-DZG01. The structures of compounds - were established from extensive spectroscopic data and HRESIMS analysis. Th...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2019-08, Vol.17 (8), p.483
Main Authors: Qiu, Pei, Liu, Zhaoming, Chen, Yan, Cai, Runlin, Chen, Guangying, She, Zhigang
Format: Article
Language:English
Subjects:
Absolute configuration
alpha-Glucosidases - metabolism
Antioxidants
Antioxidants - chemistry
Ascomycota - chemistry
Ascomycota - metabolism
asperchalasine
Carbon
Crystallography, X-Ray
Diabetes
Fungi
Glucosidase
Glycoside Hydrolase Inhibitors - chemistry
Mangroves
Metabolites
Molecular Structure
Mycosphaerella
Mycosphaerella sp
Scavenging
Secondary metabolites
Single crystals
X-ray diffraction
α-Glucosidase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four new metabolites, asperchalasine I ( ), dibefurin B ( ) and two epicoccine derivatives ( and ), together with seven known compounds ( - ) were isolated from a mangrove fungus sp. SYSU-DZG01. The structures of compounds - were established from extensive spectroscopic data and HRESIMS analysis. The absolute configuration of was deduced by comparison of ECD data with that of a known structure. The stereostructures of - were further confirmed by single-crystal X-ray diffraction. Compounds , and exhibited significant α-glucosidase inhibitory activity with IC values of 17.1, 26.7 and 15.7 μM, respectively. Compounds , , and showed antioxidant activity by scavenging DPPH· with EC values ranging from 16.3 to 85.8 μM.
ISSN:1660-3397
1660-3397
DOI:10.3390/md17080483