Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea

[...]we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride. Whole exome sequencing revealed no mutations. [...]the patient was treated with Lantus (8 U/day...

Full description

Saved in:
Bibliographic Details
Published in:Chinese medical journal 2019-04, Vol.132 (7), p.846-848
Main Authors: Fu, Jun-Ling, Wang, Tong, Xiao, Xin-Hua
Format: Article
Language:English
Subjects:
Birth weight
Chromosomes
Correspondence
Diabetes
Endocrinology
Fasting
Genomes
Glucose
Hypoglycemia
Insulin
Kinases
Laboratories
Medical schools
Patients
Semiconductors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313
cites cdi_FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313
container_end_page 848
container_issue 7
container_start_page 846
container_title Chinese medical journal
container_volume 132
creator Fu, Jun-Ling
Wang, Tong
Xiao, Xin-Hua
description [...]we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride. Whole exome sequencing revealed no mutations. [...]the patient was treated with Lantus (8 U/day) together with lifestyle modifications. [2] Given that patients with 6q24-related TNDM have relatively healthy beta cell function at remission, sulfonylurea treatment has a biological rationale in patients with 6q24-related TNDM, as its potential mechanisms are: (1) patients with 6q24-related TNDM presumably have intact sulfonylurea receptors at the pancreatic ß-cell and (2) the beta cells of patients with 6q24-related TNDM have decreased sensitivity to glucose, so sulfonylurea helps to improve the release of insulin.
doi_str_mv 10.1097/CM9.0000000000000147
format article
fullrecord <record><control><sourceid>wanfang_jour_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_e0d98d64412248309f9d43fd29d26344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>zhcmj201907013</wanfj_id><doaj_id>oai_doaj_org_article_e0d98d64412248309f9d43fd29d26344</doaj_id><sourcerecordid>zhcmj201907013</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313</originalsourceid><addsrcrecordid>eNpdUl1rFDEUDaLYtfoPRAaE4su0-c7kRZClaqFSEH0OmcnN7iyZmW2SsWx_fdNuXdrmJdx7zznJuRyEPhJ8SrBWZ8tf-hQ_PYSrV2hBBae1kJy8RgvMpKyl1voIvUtpgzEVQsm36IjhRiuhmwWyvyHYbQJXyWvK61iqXIoc7Zh6GHM1wjTabEPlettChlQNEEKf51SluesgJT-HsCsMeGDe9HldJsFP4y7MpfkevfE2JPjweB-jv9_P_yx_1pdXPy6W3y7rTjCWa0-EaBSTSqsGnHfAPbGYOuZb3mqNWQuk7aQWraMewGMuGWglmZCOKkbYMbrY67rJbsw29oONOzPZ3jw0prgyNua-C2AAO904yTmhlDcMa68dZ95R7ahknBetr3ut7dwO4LqyiGjDM9Hnk7Ffm9X0z0ihRSNUETjZC9zY0dtxZTbTHMdi39yuu2FDMdFYYcIK8MvjS3G6niFlM_SpKxu2ZfFzMpRoKaiQ5N7g5xfQgygVmErMMW0Kiu9RXZxSiuAPvybY3AfHlOCYl8EptE9PHR9I_5PC7gDdmr5O</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2502604028</pqid></control><display><type>article</type><title>Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea</title><source>HEAL-Link subscriptions: Lippincott Williams &amp; Wilkins</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Fu, Jun-Ling ; Wang, Tong ; Xiao, Xin-Hua</creator><creatorcontrib>Fu, Jun-Ling ; Wang, Tong ; Xiao, Xin-Hua</creatorcontrib><description>[...]we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride. Whole exome sequencing revealed no mutations. [...]the patient was treated with Lantus (8 U/day) together with lifestyle modifications. [2] Given that patients with 6q24-related TNDM have relatively healthy beta cell function at remission, sulfonylurea treatment has a biological rationale in patients with 6q24-related TNDM, as its potential mechanisms are: (1) patients with 6q24-related TNDM presumably have intact sulfonylurea receptors at the pancreatic ß-cell and (2) the beta cells of patients with 6q24-related TNDM have decreased sensitivity to glucose, so sulfonylurea helps to improve the release of insulin.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/CM9.0000000000000147</identifier><identifier>PMID: 30897598</identifier><language>eng</language><publisher>China: Lippincott Williams &amp; Wilkins Ovid Technologies</publisher><subject>Birth weight ; Chromosomes ; Correspondence ; Diabetes ; Endocrinology ; Fasting ; Genomes ; Glucose ; Hypoglycemia ; Insulin ; Kinases ; Laboratories ; Medical schools ; Patients ; Semiconductors</subject><ispartof>Chinese medical journal, 2019-04, Vol.132 (7), p.846-848</ispartof><rights>Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313</citedby><cites>FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zhcmj/zhcmj.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595857/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2502604028?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30897598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Jun-Ling</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Xiao, Xin-Hua</creatorcontrib><title>Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea</title><title>Chinese medical journal</title><addtitle>Chin Med J (Engl)</addtitle><description>[...]we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride. Whole exome sequencing revealed no mutations. [...]the patient was treated with Lantus (8 U/day) together with lifestyle modifications. [2] Given that patients with 6q24-related TNDM have relatively healthy beta cell function at remission, sulfonylurea treatment has a biological rationale in patients with 6q24-related TNDM, as its potential mechanisms are: (1) patients with 6q24-related TNDM presumably have intact sulfonylurea receptors at the pancreatic ß-cell and (2) the beta cells of patients with 6q24-related TNDM have decreased sensitivity to glucose, so sulfonylurea helps to improve the release of insulin.</description><subject>Birth weight</subject><subject>Chromosomes</subject><subject>Correspondence</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Fasting</subject><subject>Genomes</subject><subject>Glucose</subject><subject>Hypoglycemia</subject><subject>Insulin</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Medical schools</subject><subject>Patients</subject><subject>Semiconductors</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdUl1rFDEUDaLYtfoPRAaE4su0-c7kRZClaqFSEH0OmcnN7iyZmW2SsWx_fdNuXdrmJdx7zznJuRyEPhJ8SrBWZ8tf-hQ_PYSrV2hBBae1kJy8RgvMpKyl1voIvUtpgzEVQsm36IjhRiuhmwWyvyHYbQJXyWvK61iqXIoc7Zh6GHM1wjTabEPlettChlQNEEKf51SluesgJT-HsCsMeGDe9HldJsFP4y7MpfkevfE2JPjweB-jv9_P_yx_1pdXPy6W3y7rTjCWa0-EaBSTSqsGnHfAPbGYOuZb3mqNWQuk7aQWraMewGMuGWglmZCOKkbYMbrY67rJbsw29oONOzPZ3jw0prgyNua-C2AAO904yTmhlDcMa68dZ95R7ahknBetr3ut7dwO4LqyiGjDM9Hnk7Ffm9X0z0ihRSNUETjZC9zY0dtxZTbTHMdi39yuu2FDMdFYYcIK8MvjS3G6niFlM_SpKxu2ZfFzMpRoKaiQ5N7g5xfQgygVmErMMW0Kiu9RXZxSiuAPvybY3AfHlOCYl8EptE9PHR9I_5PC7gDdmr5O</recordid><startdate>20190405</startdate><enddate>20190405</enddate><creator>Fu, Jun-Ling</creator><creator>Wang, Tong</creator><creator>Xiao, Xin-Hua</creator><general>Lippincott Williams &amp; Wilkins Ovid Technologies</general><general>Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</general><general>Wolters Kluwer Health</general><general>Wolters Kluwer</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190405</creationdate><title>Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea</title><author>Fu, Jun-Ling ; Wang, Tong ; Xiao, Xin-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Birth weight</topic><topic>Chromosomes</topic><topic>Correspondence</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Fasting</topic><topic>Genomes</topic><topic>Glucose</topic><topic>Hypoglycemia</topic><topic>Insulin</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Medical schools</topic><topic>Patients</topic><topic>Semiconductors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Jun-Ling</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Xiao, Xin-Hua</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Jun-Ling</au><au>Wang, Tong</au><au>Xiao, Xin-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chin Med J (Engl)</addtitle><date>2019-04-05</date><risdate>2019</risdate><volume>132</volume><issue>7</issue><spage>846</spage><epage>848</epage><pages>846-848</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>[...]we report a Chinese male patient with a history of 6q24-related TNDM (hypomethylation of the maternal allele) who relapsed at 14 years old and was successfully treated with a low dose of glimepiride. Whole exome sequencing revealed no mutations. [...]the patient was treated with Lantus (8 U/day) together with lifestyle modifications. [2] Given that patients with 6q24-related TNDM have relatively healthy beta cell function at remission, sulfonylurea treatment has a biological rationale in patients with 6q24-related TNDM, as its potential mechanisms are: (1) patients with 6q24-related TNDM presumably have intact sulfonylurea receptors at the pancreatic ß-cell and (2) the beta cells of patients with 6q24-related TNDM have decreased sensitivity to glucose, so sulfonylurea helps to improve the release of insulin.</abstract><cop>China</cop><pub>Lippincott Williams &amp; Wilkins Ovid Technologies</pub><pmid>30897598</pmid><doi>10.1097/CM9.0000000000000147</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0366-6999
ispartof Chinese medical journal, 2019-04, Vol.132 (7), p.846-848
issn 0366-6999
2542-5641
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_e0d98d64412248309f9d43fd29d26344
source HEAL-Link subscriptions: Lippincott Williams & Wilkins; Publicly Available Content Database; PubMed Central
subjects Birth weight
Chromosomes
Correspondence
Diabetes
Endocrinology
Fasting
Genomes
Glucose
Hypoglycemia
Insulin
Kinases
Laboratories
Medical schools
Patients
Semiconductors
title Relapsed 6q24-related transient neonatal diabetes mellitus successfully treated with sulfonylurea
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A33%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relapsed%206q24-related%20transient%20neonatal%20diabetes%20mellitus%20successfully%20treated%20with%20sulfonylurea&rft.jtitle=Chinese%20medical%20journal&rft.au=Fu,%20Jun-Ling&rft.date=2019-04-05&rft.volume=132&rft.issue=7&rft.spage=846&rft.epage=848&rft.pages=846-848&rft.issn=0366-6999&rft.eissn=2542-5641&rft_id=info:doi/10.1097/CM9.0000000000000147&rft_dat=%3Cwanfang_jour_doaj_%3Ezhcmj201907013%3C/wanfang_jour_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c533t-f15587367978edfde4f1a02d3fb4b9903be1bc695bd2feef0463e976356d27313%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2502604028&rft_id=info:pmid/30897598&rft_wanfj_id=zhcmj201907013&rfr_iscdi=true