Adjuvant Intravitreal Bevacizumab Injection for Choroidal and Orbital Metastases of Refractory Invasive Ductal Carcinoma of the Breast

The efficacy of combined intravitreal bevacizumab injection with systemic chemotherapy, palliative radiotherapy, and hormonal therapy to treat choroidal and orbital metastases is not known. Herein, we report the case of a 48-year-old woman with systemic chemotherapy-resistant choroidal and orbital m...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2021-04, Vol.57 (5), p.404
Main Authors: Lin, I-Hung, Kuo, Bo-I, Liu, Fang-Yu
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - therapeutic use
bevacizumab
Bevacizumab - therapeutic use
Breast cancer
Cancer therapies
Carcinoma, Ductal - drug therapy
Case Report
Chemotherapy
choroidal metastasis
Drug dosages
Endocrine therapy
Estrogens
Female
Humans
intravitreal injection
Intravitreal Injections
Medical prognosis
Metastasis
Middle Aged
Monoclonal antibodies
orbital metastasis
Patients
Radiation therapy
Targeted cancer therapy
Tomography, Optical Coherence
Tumors
Ultrasonic imaging
Vascular endothelial growth factor
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Summary:The efficacy of combined intravitreal bevacizumab injection with systemic chemotherapy, palliative radiotherapy, and hormonal therapy to treat choroidal and orbital metastases is not known. Herein, we report the case of a 48-year-old woman with systemic chemotherapy-resistant choroidal and orbital metastases of the left eye originating from a stage IV invasive ductal carcinoma of the left breast. We describe the addition of a single intravitreal injection of bevacizumab in addition to treatment with systemic chemotherapy, hormonal therapy, and palliative radiotherapy. The patient's outcome at 6-month follow-up was favorable, as the metastatic lesion reduced in size and visual acuity improved. Combined treatment with intravitreal bevacizumab injection, systemic chemotherapy, palliative radiotherapy, and hormonal therapy can resolve ocular metastatic lesions originating from breast cancers.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina57050404