Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products

In our previous study, all Arthrinium isolates from Sargassum sp. showed high bioactivities, but studies on marine spp. are insufficient. In this study, a phylogenetic analysis of 28 Arthrinium isolates from seaweeds and egg masses of Arctoscopus japonicus was conducted using internal transcribed sp...

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Bibliographic Details
Published in:Marine drugs 2018-12, Vol.16 (12), p.508
Main Authors: Heo, Young Mok, Kim, Kyeongwon, Ryu, Seung Mok, Kwon, Sun Lul, Park, Min Young, Kang, Ji Eun, Hong, Joo-Hyun, Lim, Young Woon, Kim, Changmu, Kim, Beom Seok, Lee, Dongho, Kim, Jae-Jin
Format: Article
Language:English
Subjects:
Alcohols
Algae
antioxidant
Antioxidants
Arthrinium
Bio-assays
Bioactive compounds
Bioassays
Biodiversity
Biofilms
Biological activity
biological control
ecological role
Elongation
Fungi
Fungicides
gentisyl alcohol
Marine ecology
Marine environment
Metabolites
multi-gene phylogeny
Natural products
New species
Ova
Pathogens
Pharmaceutical industry
Phylogenetics
Phylogeny
Quorum sensing
Reactive oxygen species
Scavenging
Seaweeds
Symbionts
Translation elongation
Tubulin
Tyrosinase
tyrosinase inhibition
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Summary:In our previous study, all Arthrinium isolates from Sargassum sp. showed high bioactivities, but studies on marine spp. are insufficient. In this study, a phylogenetic analysis of 28 Arthrinium isolates from seaweeds and egg masses of Arctoscopus japonicus was conducted using internal transcribed spacers, nuclear large subunit rDNA, β-tubulin, and translation elongation factor region sequences, and their bioactivities were investigated. They were analyzed as 15 species, and 11 of them were found to be new species. Most of the extracts exhibited radical-scavenging activity, and some showed antifungal activities, tyrosinase inhibition, and quorum sensing inhibition. It was implied that marine algicolous Arthrinium spp. support the regulation of reactive oxygen species in symbiotic algae and protect against pathogens and bacterial biofilm formation. The antioxidant from Arthrinium sp. 10 KUC21332 was separated by bioassay-guided isolation and identified to be gentisyl alcohol, and the antioxidant of KUC21221 was identical. These results demonstrate that many unexploited Arthrinium species still exist in marine environments and that they are a great source of bioactive compounds.
ISSN:1660-3397
1660-3397
DOI:10.3390/md16120508