Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus

Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Re...

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Bibliographic Details
Published in:Viruses 2021-01, Vol.13 (2), p.211
Main Authors: So, Chui-Wa, Randall, Glenn
Format: Article
Language:English
Subjects:
Animals
Bile
Cell culture
Cell Culture Techniques - instrumentation
Cell Culture Techniques - methods
Endoplasmic reticulum
Extracellular matrix
Gene expression
Hepacivirus - genetics
Hepacivirus - growth & development
Hepacivirus - physiology
Hepatitis
Hepatitis C
Hepatitis C - virology
hepatitis C virus
Hepatocytes
Hepatocytes - virology
Humans
Infections
Liver
Organoids
Organoids - virology
polarization
Proteins
Review
Viruses
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Description
Summary:Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Researchers have begun adapting these cell culture models that morphologically and physiologically resemble hepatocytes in vivo to study HCV infection. This review summarizes the use of three-dimensional cell culture systems in studies of HCV infection.
ISSN:1999-4915
1999-4915
DOI:10.3390/v13020211