Implication of Mesenchymal Stem Cells and Their Derivates for Osteochondral Regeneration

Healing of articular cartilage defects presents a challenging issue, due to its regenerative shortcomings. Lacking vascularity and innervation of cartilage and low proliferative potential of chondrocytes are the main reasons for the limited healing potential of articular cartilage. Traditional repar...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (5), p.2490
Main Authors: Smolinska, Veronika, Debreova, Michaela, Culenova, Martina, Csobonyeiova, Maria, Svec, Andrey, Danisovic, Lubos
Format: Article
Language:English
Subjects:
Arthritis
Biomedical materials
Bone and Bones
Bone marrow
Cartilage
Cartilage, Articular
Chondrocytes
Clinical trials
Cytokines
Disease
exosomes
Healing
Innervation
Joint replacement surgery
Joint surgery
Mesenchymal Stem Cells
Nonsteroidal anti-inflammatory drugs
osteochondral regeneration
Regeneration
Review
Stem cells
Stromal cells
Subchondral bone
Tissue Engineering
Tissue Scaffolds
Transplants & implants
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Summary:Healing of articular cartilage defects presents a challenging issue, due to its regenerative shortcomings. Lacking vascularity and innervation of cartilage and low proliferative potential of chondrocytes are the main reasons for the limited healing potential of articular cartilage. Traditional reparative approaches are limited in their efficiency, hence there is a demand for novel reparative treatments. Mesenchymal stromal cells, preferred for clinical uses, can be readily derived from various sources and have been proven to have a therapeutic effect on cartilage and subchondral bone. Therefore, mesenchymal stromal cells, their derivates, and scaffolds have been utilized in research targeting osteochondral regeneration. The present review aims to comprehensively outline and discuss literature considering this topic published within last 5 years.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23052490