The Potential Diagnostic and Prognostic Value of Circulating MicroRNAs in the Assessment of Patients With Prostate Cancer: Rational and Progress

Prostate cancer (P.C.) is one of the most frequent diagnosed cancers among men and the first leading cause of death with an annual incidence of 1.4 million worldwide. Prostate-specific antigen is being used for screening/diagnosis of prostate disease, although it is associated with several limitatio...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2022-02, Vol.11, p.716831-716831
Main Authors: Samami, Elham, Pourali, Ghazaleh, Arabpour, Mahla, Fanipakdel, Azar, Shahidsales, Soodabeh, Javadinia, Seyed Alireza, Hassanian, Seyed Mahdi, Mohammadparast, Saeid, Avan, Amir
Format: Article
Language:English
Subjects:
Circulating biomarker
miRNA
Oncology
Prognostic factor
Prostate cancer
Therapeutic targets
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prostate cancer (P.C.) is one of the most frequent diagnosed cancers among men and the first leading cause of death with an annual incidence of 1.4 million worldwide. Prostate-specific antigen is being used for screening/diagnosis of prostate disease, although it is associated with several limitations. Thus, identification of novel biomarkers is warranted for diagnosis of patients at earlier stages. MicroRNAs (miRNAs) are recently being emerged as potential biomarkers. It has been shown that these small molecules can be circulated in body fluids and prognosticate the risk of developing P.C. Several miRNAs, including MiR-20a, MiR-21, miR-375, miR-378, and miR-141, have been proposed to be expressed in prostate cancer. This review summarizes the current knowledge about possible molecular mechanisms and potential application of tissue specific and circulating microRNAs as diagnosis, prognosis, and therapeutic targets in prostate cancer.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.716831